Looking at detailed myeloma information gives us an insight into what it is and how it affects us. Multiple myeloma is a form of blood cancer that develops in the soft tissue part of the bones called plasma cells. These plasma cells, also called white blood cells, are responsible for generating antibodies that are required to fight bacteria, viruses, or fungi in the immune system. While studies and reference material explaining myeloma information cannot point to ways to prevent it, an understanding of its causes and risks will help to a certain extent. Prevention Multiple myeloma is not a preventable condition, but there are certain factors that can increase your risk in developing this disease. Some of these factors are:

• Smoking
• Other forms of cancer, particularly lung cancer
• People with a history of other plasma cell neoplasms or solitary plasmacytoma

Hereditary: Myeloma information and studies prove that multiple myeloma is not hereditary. However, there are some indications that if one of the siblings is suffering from such a condition, then the other sibling is more prone to the condition due to genetic factors, which they may share. Immune system breakdown: Many types of research show that there is a strong connection between the disease and a breakdown of the immune system, which may be triggered due to various reasons as follows

• Many people working in cosmetics industries, agriculturists, those who are exposed to chemicals or pesticides have an increased risk because of exposure to such chemicals.
• Also, those who are constantly exposed to plastics, leather, heavy metals, and petroleum seem to be at an increased risk.
• The other strong risk factor is aging. According to studies, 96% of the cases are diagnosed in people over the age of 45 years and similarly, 63% of the cases occur in people over the age of 65 years.

However, research and studies about myeloma information suggest that these associations or links are not strong enough and that people unconnected to the above can be also diagnosed with these conditions.

Cooking food can be bliss or a chore depending on the appliances you buy. When you are in the kitchen, what you need is convenience and efficiency. With food piling up, maintaining stock, organizing vegetables, and making meal plans, getting good appliances for your kitchen environment becomes crucial for taste, performance, and happiness. Sears has an excellent and diverse range of kitchen appliances. You can find microwaves, wall ovens, refrigerators, cook tops, freezers, dishwashers, toasters, blenders, espresso machines, rice cookers, brewers, etc. in Sears appliances. Whether you are a hobbyist, amateur chef, professional chef, or a homemaker, these tips will help you choose the right kitchen appliances from Sears: Space When selecting kitchen appliances, space is a major factor. Consider how much space your kitchen can offer. Whether it is buying a microwave or a double-door refrigerator, estimate space constraints. This will help you purchase the right Sears appliances. Price The size and price of the Sears appliances that you buy depends on your family size and your budget. Based on the features offered, choose Sears appliances that you need. For instance, if you're buying a refrigerator, apart from space and cost, consider factors like usage patterns and personal preferences. Look compact steel refrigerators if you're hunting for minimalistic designs. Power rating How much power your appliances consume is another important point to consider. Aim for energy efficient devices or those that come with a 'SEER' rating. These appliances typically have longer shelf life, are easy to use and maintain as well. These appliances definitely cut down on your electricity bills. Comprehensively, consider the factors mentioned above, and you should be well on your way for building a savvy, and efficient kitchen space. Also, don't forget to check out the Sears appliances sales which are offered online. These sales can help you land some of the best discounts and deals on various Sears appliances.

Bottom freezer refrigerators are a pretty popular these days. There are several advantages of using this kind of refrigerator as well. However, in order to enjoy all the benefits of this particular appliance, you must buy the most appropriate one for your household. The following points should be considered while buying bottom freezer refrigerators.

• Size The perfect refrigerator for your house would be the one which is of the ideal size as per the number of people in your family. Thus, big is not always better. It is essential to pick a bottom freezer fridge which is of appropriate size. A full refrigerator is way more energy-efficient in comparison to an empty one. For instance, an 8-10 cubic foot is sufficient for a family of two or a small apartment. For every additional person, it can go up to 1.5 cubic feet.
• Accessibility Since it is bottom freezer refrigerator, look how user-friendly its design is. For instance, just check if you will face inconvenience while reaching to the food items on the lower shelves. A bottom fridge's primary purpose is to be accessible. So ensure that the model you want to buy doesn't fall short regarding this particular feature.
• Finish, style, and design The style and finish have to be considered not just while buying furniture but bottom freezer refrigerators and other appliances as well. You no longer have to choose from white, black, blue and red as far as color is considered. Apart from basic colors, refrigerators are now available in a range of colors. Therefore, you can choose a color that goes well with the decor of your kitchen.
• Price The best thing about bottom freezer refrigerators is that they are available in different price range to suit everybody's budget. There is a basic model which can be bought for a very reasonable cost, and there are high-end and more stylish built-in models which are priced at a higher amount. However, the price can be justified since there are several additional features on offer.
• Warranty Most bottom freezer refrigerators come with one to two years of warranty. It is worth looking for an extended warranty. There are extended warranties available for as long as five years as well.
• Energy guide The manufacturers need to put the yellow Energy Guide label on every appliance including bottom freezer refrigerators. This guide lets you calculate the cost of operating the appliance annually. A fridge can last up to 12 years. Keep this in mind while estimating the annual costs and compare the same with other units of the same type. The difference in the total cost of different variants will give you a clearer picture. So you can easily choose the one which is more energy efficient.
• Measure your space You may want to bring home a big refrigerator but before doing that measure space in the room where it would be kept. Do not pick a bottom freezer fridge that would not fit into space in your house. It would be a sheer waste of money. Moreover, you would find it challenging to work around a mammoth-sized cooling appliance in your apartment.

An arthritic condition, osteoporosis occurs when the bones tend to become brittle and weak. This magnifies the chances of getting a fracture even from inconsequential activities like coughing or bending. Usually, fractures related to osteoporosis are experienced in the wrist, spine or hip. It occurs when the body produces an inadequate amount of bone tissue, which is required to replace the old ones. Although osteoporosis can affect anyone, it is commonly observed among Asian and Caucasian women who have passed the menopausal phase. Usually, there are no early signs of osteoporosis, however, once the bone loss progresses, it can lead to symptoms like back pain, stooped posture, and loss of height and bone fracture that could occur even from the slightest injuries. If detected in the initial stages, osteoporosis can be managed well. Therefore, you should consider regular screening for osteoporosis if you happen to be over the age of 60 years. Diagnosis of osteoporosis The first part of the diagnosis will involve discussing medical history and performing a physical exam.

• Medical history The doctor will review your symptoms and medical history as well as any possibility of genetic conditions. They will also inquire about your dietary and lifestyle habits, which include physical activity and addiction to drinking or smoking. Along with your personal history and routine, they will evaluate any medications that you have been taking.
• Physical exam Loss of height is an important indicator of osteoporosis. The doctor will measure your height and associate it with your previous measurements. They might recommend blood tests to assess the vitamin D levels and bones' overall metabolic activity. An increased metabolic activity might point to the onset of osteoporosis.

For confirming the condition, the doctor will implement the following osteoporosis testing methods.

• Bone density test Bone density evaluation is one of the essential parts of osteoporosis testing. Usually, doctors use the dual-energy X-ray absorptiometry (DEXA) scan to determine the bone density. This kind of osteoporosis testing is quick and painless and gauges the bone density as well as the risk of fractures with the help of X-ray images. Usually, this type of osteoporosis testing is safe, however, it is not recommended for pregnant women. This is because DEXA involves exposure to a small amount of radiation, which might be detrimental to the fetus.
• Urine and blood tests Certain medical conditions can cause or accelerate the condition of bone loss. Often, these are linked with thyroid and parathyroid malfunctioning. To verify this, the doctor might perform urine and blood tests to assess the thyroid function, calcium levels, and testosterone readings in men.

Advantages of osteoporosis testing It not only allows your doctor to identify the condition but also helps them to pursue the right treatments and preventative measures. An osteoporosis testing assists the doctors to track the progress of the osteoporosis treatments.

Anything that disrupts the normal functioning of the body can create great discomfort to the person affected by it. Chronic pain is one of the primary reasons that prevent people from leading a normal life. This chronic pain can be a result of a surgery, trauma, or any pain-inducing physical ailment. As a way of coping with the nagging pain which can range anywhere between moderate to severe, doctors often prescribed opioids to such patients. Opioids are painkillers that are used to control pain caused due to a variety of reasons; but, these can pose a threat because patients tend to get addicted to opioids. In fact, tolerance and the dependency on these medications are the two common side-effects of opioid. All sorts of addictions have the ability to wreak havoc in one's life, and opioid addiction is no different. However, like every other form of addiction, opioid addiction can be treated as well. People battling this form of addiction either get themselves checked into a rehab or opt for other forms of opioid addiction treatment, which usually involves the use of medications. The medications that are used to help the individual battle their opioid addiction are as follows: Methadone Methadone is one of the FDA-approved medicines used for opioid addiction treatment and does a commendable task of helping the patient battle the addiction. Methadone is a synthetic opioid agonist and helps in treating opioid addiction by eliminating the withdrawal symptoms. It promptly relieves the cravings by nullifying the effect of the medication on the opioid receptors in the brain- these receptors are the ones that are activated by heroin, morphine, and other forms of substances. Though Methadone doesn't leave the patient feeling euphoric once the opioid addiction treatment is completed, it has been used successfully for 40 years to treat opioid addiction. Buprenorphine Buprenorphine is another medication that is used to combat the effects of opioid addiction. Unlike Methadone which is a complete agonist, Buprenorphine is a partial opioid agonist. It implies that this medication has the ability to bind to those same opioid receptors like Methadone, but activates it less strongly than the regular, full agonists do. This medication helps in reducing the craving and withdrawal symptoms and helps treat opioid addiction without experiencing euphoria. However, one can see the effects of this medication only when proper doses are administered. Naltrexone Naltrexone is an opioid antagonist, which implies that it helps in opioid addiction treatment by completely blocking the activation of the opioid receptors. Also, unlike Methadone and Buprenorphine, Naltrexone neither controls one's withdrawal symptoms nor does it reduce their cravings. To simply put it, Naltrexone works by preventing any of the opioid medications from producing any sort of rewarding effects. Though these medications are effective in opioid addiction treatment, each of these work differently. It is imperative that one consults their physician since self-medication is dangerous.

One of the most pleasing words in the world is “sale”. If you are a vehicle owner, then life gets even better if you spot a signboard that says, “Tires for Sale”. When you are looking forward to purchasing a tire or a tire set for your car, look out for tires for sale. There are many websites that offer you tires for sale and you can make the most from their offers and discounts. Below is a list of the best of the tires that are available for sale by various brands. This will give you an idea about the deals on tires and help you choose the one that is perfect for your vehicle.

Ford Sale

The website of this auto company has a special section called "Service & Maintenance". This section talks about "Tire Finder" which is a convenient platform created for the buyers to identify the most suitable tires for their vehicles. Using the Tire Finder, you will get Tires for a low price with a set guarantee. This deal is applicable to all the 13 of Ford’s tire brands. Ford also offers free installation of all the products that they offer during the tire sale.

Goodyear Tires

One can save 50% super discount on a purchase of a four-tire set on Goodyear’s website. Referred to as the President ‘s Day Tire Sale, this deal is applicable on all the Dunlop and Goodyear tires. There is also $200 cash back on Goodyear's Assurance WeatherReady and another offer in which there is a discount of up to $160 on buying a 4 tires set. Both the deals expire on March 31, 2018.

TireBuyer Sale

This spring sale has extremely generous offers for its customers. One can avail a rebate of around $40 on an order of $400 by using the coupon FEB40. The tires will be delivered for free to a local center for installation. On buying Goodyear tires, customers get an up to $80 off on a range of selected tires. There are exclusive offers on tires for military personnel. Veterans, active duty military officers and their relatives get a 7% discount. The buyer has to present a valid identity proof to avail the offer. Once the identity proof is approved, there will be a 7% rebate on the overall bill during the checkout.

Discount Tire sale

During the President’s Day bargains, customers can save a whopping amount of up to $320 if they use their VISA Prepaid Cards to buy a four tires or wheels set through their Discount Credit Card. In yet another deal of this tire sale, if one buys a four Pirelli tire set, they can get a discount of around $70 on using their Prepaid Master Card. The set of tires must be bought for a single vehicle. The customer can download the rebate form from the website. All the rebate forms must be submitted on or before a pre-defined date. Along with the best quality products, tire sales from Discount Tire can fetch you huge savings. There is also an offer on Goodyear Tires during the sale on tires. Customers can use the offer code 718002 to avail a maximum discount of up to $80 on buying a four-tire set. All the four tires must be bought at the same time. This offer is applicable on the tires mentioned as follows, Wrangler MT/R with Kevlar, Assurance Comfortred Touring, Eagle F1 Asymmetric All-Season, Assurance WeatherReady and Wrangler All-Terrain Adventure with Kevlar. Customers who purchase Wrangler TrailRunner AT and Wrangler Fortitude HT get up to $70 back. Customers who receive up to $60 discount are those who buy Ultra Grip Ice WRT, SP Winter Sports 3D, Ultra Grip Ice, Eagle Sport All-Season and SP Winter Sport 4D tires. For availing a discount of $40, the customer must buy a four-tire set of any of the following - Ultra Grip Winter, Assurance All-Season, Assurance Fuel Max, Assurance CS Fuel Max, Fierce Attitude M/ T, Winter Maxx and Wrangler SR-A. From the tire sale, if one buys Wrangler DuraTrac, they get to save around $50.