Neuromuscular disorders are medical conditions in which the neurons that control your voluntary muscles are affected. The neurons that send signals to your voluntary muscles die or break down, and this leads to serious problems like muscle wasting, and joint and mobility problems. In severe cases, neurological disorders can also lead to cardiac-related diseases or lung problems. In this article, you will be learning about some of the most common neuromuscular disorders that people suffer from today. Amyotrophic lateral sclerosis (ALS) ALS is a progressive neurological disorder in which the brain cells called motor neurons are affected. These neurons are responsible for the movement of various parts of the body. People who develop ALS gradually experience a full physical disability. Charcot-Marie-Tooth disease It is an inherited disease that is due to the mutation of the genes that affect the nerves of your hands, feet, and arms. A person suffering from this disorder is most likely to experience a loss of pain sensation, loss of muscle contraction and weaker muscles in the affected area. Multiple sclerosis Multiple sclerosis is an autoimmune disorder where your own immune system attacks the myelin sheath that protects the nerve fibers. This leads to situations where your brain is not able to communicate with the other parts of your body through the nerve signals. Muscular dystrophy Muscular dystrophy refers to a group of disorders in which the person experiences a progressive loss of muscle mass and strength. It is most common in men, especially young boys. Myasthenia gravis Myasthenia gravis is a condition where your voluntary muscles weaken and experience fatigue. Some of the common symptoms that will help you identify this disease are a weakness in the leg or arm muscles, droopy eyelids and trouble with chewing, swallowing, and speech. Myopathy Myopathy is a neuromuscular disorder in which the muscle fibers are affected. You can recognize a case of myopathy from common symptoms like muscle cramps, stiffness and muscle stiffness. Myositis Myositis refers to a medical condition that leads to inflammation in muscles. This inflammation could be a result of some injury, infection, autoimmune disease, or some medication. Spinal muscular atrophy Spinal muscular atrophy is a disease that affects the motor nerve cells of the spinal cord. It is most common in children, and a major concern in their case is that the disorder brings weakness in muscles that control breathing. In most cases, genetic factors or some immune system disorder is responsible for the development of neuromuscular disorders. There is no cure for neuromuscular disorders so the only goal of all the treatment options for these disorders is to help you manage the symptoms better, increase your range of movements and to strengthen your muscles and joints.

If you are planning to buy appliances from KitchenAid Pro but have a limited budget, then you should shop for them online. Primarily because you can grab some great price deals that will justify your budget. Secondly, if you can't find a particular KitchenAid Pro product in an electronics store, then you will most probably find it on e-commerce websites. However, before shopping for KitchenAid Pro appliances online, you should take care of the following mentioned factors.

• Select authorized stores - There are several online stores, which sell KitchenAid Pro stocks online. However, all of them are not authentic. Therefore, before placing your order for their appliances, you should ensure that they are authorized for selling these appliances. To verify this, you should check out the consumer reviews for KitchenAid Pro appliances offered on these websites.
• Check for the guarantee on the item - Stores which are licensed to sell Kitchenaid products can offer you a legit warranty on the appliances. Whether it is a servicing contract or a replacement warranty, they can provide you with all. However, the third-party stores, which are not authorized for the work, will not be able to offer you such deals and you might have to spend extra money on repairing the appliances if needed. Apart from the warranty or guarantee of the manufacturing brands, you should also check for the return or exchange policy of the stores. This will help you get the product altered in case of any damage.
• Know your requirement well - As you will not be able to see the products physically, it is imperative for you to know your requirements well. This will help you in Buying KitchenAid Pro appliances, which offer relevant features to meet your demands. If this is not done correctly, you may end up purchasing appliances with mismatched or inadequate features, and you might have to deal with hassles related to return or exchange.
• Search for special deals or discounts - When you are purchasing Kitchenaid Pro appliances online, you can always search for special deals or discounts. Almost all stores offer some special deals at different times of the year and landing any such deal can help you save money. However, you should not compromise on the product quality or features to get hold of discounts or promotional offers.

There is no dearth of online stores selling Kitchenaid items. However, all of them may not have shipping facilities in your region. Therefore, it is recommended for you to check these minute details before placing the order. Always verify the payment security measures adopted by the store to make your financial transactions safely.

Every consumer who is looking to buy a new refrigerator will want an appliance that will help to save his energy bills and money. Conserving energy in any appliance is of utmost priority these days. Refrigerators alone consume more than most appliances combined in one house. There are so many questions running through one’s mind when it comes to improving the energy efficiency. Before learning ways to improve efficiency, let us understand that cold air transmits through the heat in the refrigerator. A full refrigerator is considered more energy efficient. But it only works better if there is enough room between the items for the air to flow. Here are some of the ways in which one can improve the energy efficiency in a refrigerator:

• Keep off the top

People usually keep stuff like cereal boxes on the top of the refrigerator. Due to this, the heat cannot escape and it takes a longer time for the refrigerator to cool down. This can drain the energy.

• Condenser coil

The condenser coil located at the back of the refrigerator needs regular cleaning. Dust and webs block the heat from going out. These coils are the cooling agents for the refrigerator. Even the best refrigerators will not function well if the condenser coils are not cleaned at regular intervals.

• No longer open doors

Nothing consumes more energy than an open refrigerator. When the door is kept open for a long time, the cold air leaks out and then it takes up a lot of heat to cool the system.

• Off the ice maker

Ice makers, though are very convenient for the users for dispersing ice, often tend to eat up the energy by 14-20 percent. If, not using them, turn it off and switch to ‘ice cube tray days’ to conserve the energy.

• Ventilation

Proper ventilation is necessary even for the best refrigerators. The refrigerator should be placed at least 2 inches away from the wall to let the heat pass through the condenser coil. If the heat does not pass through, then the refrigerator has to work hard to cool down.

• Check gasket

It is important to check any unwanted open seal while closing the refrigerator door. Doors that are not properly sealed can let the cold escape and in return use up the energy. If you find the seal left open, replace the gasket.

• Organize and arrange

You can get the best refrigerators, but if you do not organize or declutter it occasionally, then even the best refrigerators will not be of any use. When food items are properly organized, it is easier to locate and you will not have to keep the door open for more time to find it. Large and bulky food items that take up too much space like bread or pizza boxes should not be kept on the top shelf as there are chances of the heat being trapped. The compressor will have to pump more to cool the refrigerator thereby shooting up your energy bills.

• Cool it off

Wait for the leftover food to cool off before stashing it in the refrigerator. Do not keep hot items in the refrigerator.

• Clean up accumulated frost

In older refrigerators, users had to manually defrost the ice buildup. Ice accumulated near the coils can make the refrigerators work overtime. Today, while the best refrigerators come with better technology and best results, it always pays to be alert in order to save energy consumption. As they say `A stitch in time, saves nine’, it is good to be cautious rather than be sorry. Some of the best refrigerators in the market today have  a lifespan of around ten years. Always go for energy efficient appliances to save your energy bills in the longer run.

Bladder cancer is considered as the most common types of cancer and is likely to affect men more than women. Recently, the Food and Drug Administration (FDA) approved the use of Nivolumab for the treatment of patients who have bladder cancer. The combination of Nivolumab and Ipilimumab was evaluated in an appearance I clinical trial. In a recent research, 41 patients were treated with a Nivolumab 1mg/kg plus Ipilimumab 3mg/kg dose, out of which doctors got few positive and good results. Nivolumab is used for the treatment of metastatic bladder cancer among patients whose disease has gotten worse. The FDA approval given to use Nivolumab for the treatment of metastatic bladder cancer was on the basis of the results of Nivolumab clinical trial, which gave positive results. Nivolumab clinical trial was done on 270 patients who were suffering from advanced or metastatic bladder cancer that had worsened over time. 19% of these patients who received Nivolumab had tumor shrinkage for a median of 10.3 months. Out of 53 patients who had tumor shrinkage, 7 patients had complete tumor shrinkage and 46 patients who had partial tumor shrinkage. Nivolumab functions by releasing a protein called Pd-1 on cancer-fighting immune cells called T cells. Once Nivolumab releases PD-1 protein, T cells can destroy the cancer cells. Implications of Nivolumab As there were few options available for treatment of metastatic bladder cancer, doctors started using Nivolumab soon after Nivolumab clinical trial results were approved by FDA. In contrast to typical short-lived responses with cancer therapy in solid metastatic tumors, many responses induced by Nivolumab appear persistent. These persistent results only increased the use of Nivolumab for people who have metastatic bladder cancer. Note of caution If a patient is or was on some prescribed drug or has used some herbal products, then he/she must tell this to the doctor before using Nivolumab. Although Nivolumab clinical trial results are positive and FDA-approved, there are many drugs and over-the-counter medicines, which can interact with Nivolumab and deteriorate the situation.

Gone are the days when a reward for being good comprised watching cartoons on TV for one hour. Today, kids are more tech-savvy and tend to be screen hungry. Nowadays, one hour of watching cartoons does nothing for their entertainment or learning. Therefore, we are in the right time and place to buy the best tablets for kids that will help them keep up their pace in today’s fast-moving world and find some entertainment that fits their age and mental abilities perfectly. If you are looking for a good tablet for your kids that have the right amount of features, like parental locks and efficient screen settings, here is two of the most popular kids' tablets that you can buy for your smart kids. Amazon Fire HD 8 Kids Edition Tablet This is the kid’s version of the Fire tablets made for adults. This tablet comes with free access to Amazon FreeTime Unlimited for one full year. It also has a two-year guarantee. Amazon FreeTime lets you find great books, movies, and TV shows which are kid-appropriate, all in one place. With this unlimited subscription, you do not have to look into various apps to find different content. It has parental controls as well, such as options to set time limits so that the content is automatically blocked when the time is up. There is also an option of age filters so that your 3-year-old will not see content meant for 12-years-olds and so on. With this tab, you can also choose to give access to Netflix and YouTube. Kurio Xtreme Next Tablet Kurio Xtreme Next Tablet is one of the best tablets for kids. It is a best-seller and offers great features. This tablet is a budget tablet for kids, and it comes with a lifetime subscription to Kurio Genius, which is an internet filtering system. It gives access to 1.8 billion websites in 200 different languages. This tablet also comes with pre-downloaded apps like educational content, YouTube kids, and games from Google Play. Kurio also offers Surprise-A-Week programs, which gives kids an app, a new book, or an e-book every week for free. There are also some good parental controls, like app management, time limits, and the option of creating child profiles for as many as 8 children at a time. You can choose the right one based on which suits your requirements best.

Customizing your mobile phone cases has got to be one of the most creative aspects that have popped up in the cellphone industry. It is literally like dress-picking outfits for your cell phone daily. Gone are the days when the cell phone cases used to be the mundane black, brown or the transparent ones. Nowadays, with a plethora of choices and themes available, one can have images on the cover, have themes (such as nautical theme, rugged theme, nature theme and what-not), and even have famous quotes printed on from movies and series, all according to one's likes and moods. While one can customize prints on plastic mobile cases, today there are options to customize the leather android cell phone cases too: Personalized Designer Cases: Designer cases are the designs which are already completed and ready for sale. Customizing these types of cases can be done only by adding a particular name or quote to the case, and not changing the design in entirety. For instance, if the background is white with the design only in partial space, one can request for the quote (or even one's name) to be printed in the rest of the space. For those people looking for some more bling, these cases even come embellished and adorned with sparkly backgrounds and fancy stones. Custom photo cases: Customizing designer mobile cases is not just about writing names or quotes one of the most popular ways of customizing android cell phone cases is by adding photos. Whether it is the perfect family photo captured with your camera or your favorite TV series cast photo or even a great nature shot, one can get it printed either across the case as a single photo or, even better, in a collage format. Customizing mobile cases could be more attractive for the kids because they get to embellish their favorite cartoon character or their first work of art. Popular designs: After scoring a lot of websites, we have listed the most popular designs for you these include cheetah and leopard prints, plain shaded vibrant colors, zig-zag designer prints of different shades with a plain background etc. are the most popular customized designs. One can even find the user's name printed on a plain white/black background as a very common custom design. The only drawback of customizing cases is that they don't provide protection against rain, aren't shock-proof, etc., and only add good looks to the phone. Customizing is all about getting what you like on your mobile case. It is usually done on plastic cases but it again depends on the store options. With technology and customer satisfaction at its peak, one can get it done through online shopping websites as well.