What is multiple myeloma? The fundamental cause of cancer is the abnormal multiplication of cells in our body. Cells of any part of our body can become cancerous and this disease may spread to other parts of the body as well. When plasma cells become malignant, then this medical condition is called multiple myeloma. These cells reside in the bone marrow and play an important part in our immune system. They work together in fighting off the various infections and diseases that may affect our body. Lymphocytes or the lymph cells form an important part of the immune system. These cells are of two types- T cells and B cells. When there is an infection, the B cells become plasma cells. When they go out of control, they are called a plasmacytoma which is a kind of tumor. If a patient has more than one plasmacytoma, then he is suffering from multiple myeloma. How is multiple myeloma treated? There are various kinds of multiple myeloma treatments available to the patient. These are: • Chemotherapy and taking other drugs • Using bisphosphonates- Myeloma cells can weaken, dissolve or even break the bones where they are lodged. Bisphosphonates help the bones stay strong by slowing down this process. • Using radiation • Taking recourse to surgery • Stem cell transplant- In this process, the unhealthy and diseased blood cells are killed by drugs and radiation. These unhealthy cells are replaced by healthier blood cells to regenerate themselves. • Plasmapheresis- This is a process that removes the myeloma protein from the blood. Often this protein causes the blood to thicken beyond acceptable levels. Blood thickening can cause interference in blood circulation. Before opting for one of these treatments, please check with your doctor to determine the right treatment. Many insurance companies insist that you take a second opinion before getting treated for multiple myeloma. Complementary and alternative approaches Your doctor may not have mentioned some complementary and alternative methods of treating multiple myeloma. What are these? • Acupuncture • Massage • Special diets • Herbs • Vitamins Complementary methods are those that you can continue while you are following the advice of your doctor. Alternative methods are those that you take without following your doctor's treatment. Please consult your doctor or your cancer care team in case you want to follow a complementary or alternative approach. While some of these methods may relieve you of your multiple myeloma symptoms, others may prove to be dangerous. Features of multiple myeloma 1. Low blood count- This happens because the overgrowth of plasma cells crowds out the healthier blood cells. As a result, there is a substantial dip in the red blood cells. Platelet count also comes down and there is heavy bleeding in case there is an injury or a bruise. White blood cell count also comes down significantly, as a result, the patient suffers from frequent infections. 2. Other characteristics include problems related to bones and calcium, infections, problems related to the kidneys, monoclonal gammopathy etc.

Due to the advertisements that retailers run all through the year, it might seem to you as if they are running the sale all through the year at the major stores. There are specific times of the year when certain items sell more than the others and these retailers know that very well. These businessmen know very well that seasonal sales can prove to be very profitable if the promotional aspect is taken care of. As the intelligent and smart buyer, you must know just the perfect time when you should buy your clearance refrigerator so that you save on the hard earned money that you can possibly spend on other important stuff. There is a system according to which the sales take place, and let us now have a look at it, carefully. This would help you get a clear picture of the times that are suitable for buying clearance items so that if you miss one sale, you can stay prepared for the next with time in hand.

Seasonal cycle

The first seasonal cycle that you would have the opportunity to make use of is the January cycle. Think of the time—Christmas is just over, and there would be a rush on the part of the retailers to clear off stock that had been brought in for Christmas. So, you must look for the advertisements for any sales that they put up, and that would enable you to get your clearance refrigerator at a great price. February is not far behind from the sales perspective. If January has the post-Christmas spirit up its sleeve, February comes armed with President’s Day and Valentine’s Day. Although the main products that get sold at this time are cards, flowers, chocolates, and teddies, this is also a time when the electronics sale is on. So, if you have the resources, there is no reason why you should not look up to February for your purchase. The next couple of months are not that suitable for the sales of electronic items, but if you are careful enough, you might still find one or two such sales going on. Especially you should look out for refrigerators in April because this is the month during which the Easter holidays fall, so there might be a sale going on in the vicinity. If you want to gift one to your mother on Mother’s Day, May is the time you can buy as there would be clearance sale for refrigerators. This would be quite a good time to buy it even if you are buying it for yourself. The other occasions in this month are Cinco de Mayo and Memorial Day, so you can keep an eye on the sales column in the newspaper. The next two months are June and July and they bring up two occasions—Father’s Day and the 4th of July. There would definitely be a sale on the 4th of July and on Father's day, and you can expect great discounts on refrigerators of all kinds and brands. You can even search the websites of your dealers and retailers nearby and see if they have put up any hint of an upcoming sale.

Sale Bonanza

Barring the month of August, the latter part of the year has a lot of offers. September has Labor Day coming in and the clearance refrigerator can be bought during this onrush. October brings Halloween, November brings in Thanksgiving and of course December ushers in the much awaited Christmas. So, these are the months to watch out for. Online shopping could be a good idea if you want to be really sure about the actual selling price of your clearance refrigerator and it is a good way to compare prices to determine the best price.

Honda’s Civic series has always been popular in the market due to its reputation of being eco-friendly, fuel efficient, and a steadfast performer. The used Honda Civics also get the same reputation as a new one when maintained well, and they go higher up in resale market value when compared to other cars in this category. The used Honda Civic available in the market can range from being sporty and classic to fuel efficient, low Co2 emitting, and budget fitting provided the buyer buys from appropriate sellers. Advantages of buying a used Honda Civic: The contemplation of buying a new car versus an old used one always strikes the mind of the buyer and the answer to that question lies in the needs of the buyer as well. The primary reason to pick a used car is that it saves a huge dent on the wallet and because the used cars do not depreciate in value as fast as a new one. The value of depreciation of a new car begins the moment the car is taken out of the showroom. On choosing to get a used Honda Civic, the buyer can get it for just a fraction of the price of a new one. How to get a reliable used Honda Civic: Doing a thorough research is essential when setting out to buy a used Honda Civic. Get a history report of the car so that you can check the car’s past maintenance, damage/accident history, and any major repairs/reconstruction done. Buy a car that has minor red flags so that your post-buy rate of expense is only maintenance and not major repairs. Run a comparative check of the Honda Civic’s current market rate as well as a used car’s going rate. To check, a buyer has to just enter the make, model, and year, on any trustworthy website. As a buyer, you must also check the mileage and condition so that you do not end up paying more than what is the usual going price. A used Honda Civic can be purchased from Honda dealers with CPO programs, local car dealers, private or online sales.

With the advancement in technology, it has become easier for one to manage their daily chores more efficiently. The invention of household appliances has been a great help to all those who are trying to juggle their job and home together. GE is one such appliance brand that has gained the trust of customers worldwide. With over 125 years of business in electrifying and modernizing homes, GE appliances offer premium packages for your kitchen and understand the needs of a modern home. In a modern home, electronic appliances have made their place everywhere, from the living room to bathrooms. However, the one place that needs it all is the kitchen. An urban kitchen, hence, needs quick, hassle-free, and seamless functioning appliances. Microwaves, dishwashers, refrigerators, ovens, and cooktops are important parts of the modern kitchen today. Investing in these kitchen appliances, however, can sometimes go out of your budget. The price of a single appliance may sometimes run into more than a thousand dollars. As a buyer, you can save a lot more if you buy appliances in a package. GE, or General Electric, offers its premium kitchen products in savings packages too. If you are upgrading your kitchen, it would be a good idea to invest in a GE kitchen appliance package. GE, through several outlets, offers kitchen appliance packages that you can choose from. Based on your needs and budgets, these packages are everything you can ask for, and all for a less price, of course!

How to choose the perfect kitchen appliance package?

GE has quite a large range of kitchen appliance packages that you can choose from. Mentioned below are a few tips to choose the right kitchen appliance package.

Understand your needs

There are many kitchen appliance packages that are available in the market. You could get overwhelmed with the possibilities. GE kitchen appliances come in many ranges like Steel Range, Silver Range, and Cafe Suite. Many retail stores offer online price and range comparison. Before you check them out, it is important to know what would fit and what would not. You have to see whether the appliances are too big or too small for your space. Not to mention, the installation charges and maintenance. Once you are clear on these aspects, you can move on to buying.

Compare various GE kitchen appliance packages online

Before you decide on a package, it is advisable to compare it online. Various websites offer comparisons on different types of GE kitchen appliance packages. They have a wide range of offers and can ease your stress of choosing a perfect range. For instance, a curated range on one such website includes four pieces of kitchen appliances. These four pieces include a side by side refrigerator, a dishwasher, a microwave, and an electric range. However, each range includes products of different capacity. On Brandsmart USA, you can select similar ranges but also go through user reviews. You can choose from steel range, slate range, and other GE kitchen appliance packages here. Once you compare these product packages, you will have a clear idea of what you want to buy. There are many other retail websites that offer similar ranges. You can browse through them and find the one that meets your needs.

Tips to keep in mind

Once you know what you need and have done your research, you can move on to buying. See whether the GE kitchen appliance package that you have chosen comes with a warranty. Check about after-sales services as well as how the appliances fit into your living space. Remember to check the appliances that you buy before bringing them in. GE kitchen appliance packages would help you set your home the way you want to. You can also make your own package by going through the GE website which puts up many offers. You can choose the one that suits your needs best. You can also contact them for more information for buying the packages that are best for you. Once you follow the above guide, buying kitchen appliances would not be a burden.

Samsung Galaxy S8 is the latest flagship phone released on the market by the smartphone giant. Just like with every flagship phone launched by Samsung, the Galaxy S8 has been launched with a display more commonly known as the Infinity Display. The display is called so because of its screen to body ratio that is minimal, giving a clear view of the immediate background from the side panels. The Galaxy S8 has a lot more features to boast about apart from its display. It comes with a 5.8-inch Quad HD Super AMOLED display with a density of 570 pixels per inch. Its rear camera has a 12MP autofocus lens with optical image stabilization and f1.7 aperture. The Galaxy S8 along with S8 Plus comes with a 64-bit processor along with a 4GB RAM and 64GB internal storage. The phone has the option for expandable storage of up to 256GB. To discuss the Infinity Display of the S8 and S8 Plus, we must understand that both these phones do not have any bezel around them extending across the screen display. Another area where the S8 beats all other phones in this range is the security it offers to its users. Incorporated with a fingerprint sensor on the back with an iris scanner in the front, it ensures that your data is safe and secure and can be accessed only with your permission. Along with these, the phone offers a waterproof and dustproof body that lets you use the phone to its full extent even in extreme rains. The Samsung Galaxy S8 and Samsung Galaxy S8 Plus are available in different colors. The best deals for Samsung Galaxy S8 Plus are available on popular e-commerce websites like Amazon. When you place orders for Samsung Galaxy S8, you can be assured of the best price from online retailers. Samsung also offers free accessories along with the phones; these include wireless charger, Gear VR, and a 360° camera. The features offered and the gadgets available as accessories make the Galaxy S8 prices apt and make it the perfect smartphone for business use as well as for making a style statement. The Galaxy S8 news and reviews suggest that this phone and its Infinity Display are the best things this year.

Since the 1970s, Topman has catered to male fashion and rules the niche market for its products. The clothing and footwear are not only affordable, but are also stylish and creative. When it comes to male fashion styles, people often wonder what is it that you need to look for? The answer is quality and functionality. Something as simple as a t-shirt should exude a classy yet comfortable vibe. And who can forget shoes? Staple for every man, Topman men shoes are something worth investing in. Topman have a large variety of shoes for your perusal. All you have to do is to select the occasion formal or casual and you are good to go! Here are a few staple Topman men shoes that you need to have in your closet. Loafers Loafers are the in footwear option for every season. Their ankle length tops make them suitable for casual as well as formal settings. Topman offers classic and quirky designs that you can alter depending on where you are. For example, if it is a business meeting, you can wear patent black loafers with socks and trousers for a sleek look. But if it's a lunch scene with your buddies, you can try out the beige faux suede tassel loafer. Pair it up with jeans and a casual white button-down shirt to complete the look. And if you don't mind experimenting, you can even buy red or blue velvet loafers for a snazzy dance party! Sliders Many of us prefer flip flops when it comes to slip-on shoes. But if you are someone who frolics on a beach or pool side during summer, Topman offers excellent choices of sliders. The good thing about sliders is that they are completely made of rubber. So you can get them wet and not worry about it. Also, drying them out in open can keep them free from odor. Sliders are easy maintenance and you can choose different materials too. Topman offers different styles depending on where you are going to use them. A pair of sliders, thus, can be your summer staple! Boat shoes Topman offers boat shoes made by Sperry, a leading brand in footwear industry. Initially, dock workers wore boat shoes as they had rubber soles for better grip. They have now become a casual footwear option. You can buy boat shoes and use them when you know you will be mostly on a wet surface through the day. These shoes are not for rough terrain but look good if you are on a beach, poolside, or just at a cafe with friends. Shop Sperry boat shoes on Topman, in brown color with handmade construction. These shoes are what you need to have in your wardrobe. So pick one from the wide range that Topman offers and rock it!