Blood is circulated to all parts of the body through the circulatory system. Blood pressure is the force or pressure with which it is circulated all through the body. Maintaining the blood pressure within the normal range is vital to the smooth functioning of all the organs. Blood supplies oxygen and other vital nutrients to various organs of the body. Proper supply of these nutrients happens only when normal blood pressure range is maintained. Apart from these nutrients, blood also supplies antibodies and hormones throughout the body. The heart is the main source of blood pressure. It functions like a pump that continuously pumps blood to the circulatory system. Blood is forced out during each contraction. The blood flow throughout the body is due to different pressure levels for various parts. Blood pressure is highest at the point it is pumped out of the heart, from there on its pressure decreases. The pressure is lowest at the smaller branches of arteries. The walls of the arteries are elastic, which helps in maintaining the blood pressure and allowing free flow. A sphygmomanometer is used to measure blood pressure, and its measure unit is in mmHg. Normal Blood Pressure Levels based on Age Physicians rely on blood pressure level charts to check and compare measured blood pressure with the against normal range. The blood pressure chart can be used as a reference for adults of any age. The National Institutes of Health has fixed the normal blood pressure as 120 mmHg as systolic and 80 mmHg as diastolic. According to the American Heart Association, 130/80 is considered as high blood pressure. Blood pressure charts for adults show that low blood pressure range is from 70/40 to 90/60. Ideal blood pressure ranges from 90/60 to 120/80. From 120/80 to 140/90, it is considered as pre-high blood pressure. From 140/90 to 190/100, it is considered high blood pressure. In addition to the readings, physicians also consider the age of the patient during diagnosis. Those with more than normal blood pressure need to adopt a healthy lifestyle to prevent the development of cardiovascular diseases. The condition of the arteries is extremely important in maintaining a normal blood pressure range. Constricted or narrowed arteries alter the pressure causing it to fall out of the normal blood pressure range. Altered blood pressure, when left unchecked, may lead to serious health issues.

Although cleaning the floor is a mundane job, it has to be done to ensure proper hygiene of a place. This is the reason why thorough cleaning of floors is important. It needs the help of the best floor cleaners to do the job. This article provides certain tips, which if followed, can make the cleaning process not only easy, but also painless. Tips Floors attract all kinds of dust, dirt, grime and other elements. They get dirty easily as gravity attracts everything on the floor. They are also the main pathways inside the home and people have a tendency to drag everything from outside onto the floors. Each floor is made of different materials and therefore the cleaning procedure also has to be different. Whatever be the type of floor, choose the best floor cleaners so that there is no harm to the environment, small children or pets. Moreover, you must check whether the ingredients are natural or not. The first thing that has to be kept in mind is the surface of the floors which needs to be cleaned. Wooden floors need different types of cleaners than the non-wooden ones. The carpets with fibers also call for an entirely different floor cleaner. Once the actual material is determined, you will be easily able to zero in on the right cleaner for the floor. Remember, just going by labels to arrive at a decision is not prudent. For instance, a chemical floor cleaner, irrespective of the branded, should never be purchased. This will not only ruin the floor, but will also affect the residents. If the floor gets damaged, one might have to spend millions of dollars in replacing or repairing it. Sometimes, all that is needed to clean a floor is a mild soap and warm water. Laminate floors have to be cleaned on a regular basis. So, the cleaners for them should also be of a special type. The laminate does not need expensive cleaners to look the best. Only the dirt and the dust need to be swept away from them. The best floor cleaners for laminate floors are essentially the ones that will not damage the floor, yet solve the cleaning purpose. The only thing to be kept in mind is that laminate floors should not be soaked for a long period of time. Types of floor cleaners There are various kinds of floor cleaners available in the market. Some of them are listed below! Wood floor cleaners Laminate floor cleaners Steam floor cleaners Of these, steam cleaners are eco-friendly devices as they do not use chemicals. They are much better than the mops and can give long-term services. This is because it uses pads and cleaning solutions, which do not have to be replaced on a regular basis.

What is multiple myeloma? Cancer could be present when there is an abnormal cell growth in any part of the body. The bone marrow of our body produces a type of bold white cell called plasma cells. When these plasma cells show abnormal growth, it causes a type of cancer called myeloma or multiple myeloma (as it affects multiple parts or regions of the body). It is a rare and incurable disease. In the US, the risk of getting this cancer is 0.7% or 1 in 143 people. As multiple myeloma does not have any permanent cure, there is a chance of it recurring. This reoccurrence of cancer even after treatment or remitting, is known as relapsed multiple myeloma. Even though the disease is incurable, patients with relapsed multiple myeloma need to consult a doctor as soon as possible. Treatment for myeloma Treatment would depend on the stage of cancer and the overall health of the patient. Introduction of new therapies and drugs helps in delaying the relapse after initial treatment. Controlling and destroying myeloma cells or curing ailments caused due to myeloma, helps to increase the chances of the patient’s survival by a few years. The following medications are conventionally used in treating multiple myeloma:

• Precision medicines (Darzalex, Farydak, Simplicity)
• Immunomodulatory drugs,
• Proteasome inhibitors
• Chemotherapy and
• Steroids

Unfortunately, even with all these medications, a relapse cannot be prevented. Researchers are finding ways to extend the life of patients by increasing the remission period. For killing cancer cells, high doses of chemotherapy are considered more effective. But it has dangerous side effects such as damaging healthy cells in the bone marrow. Though, this can be corrected through a stem cell transplant. Stem cell transplant has been effective in preventing relapsed multiple myeloma. Patients are advised to go for regular health checkups even during remission period. So that if and when cancer relapses, doctors can begin immediate treatment based on the cause of relapse and the overall health of the patient. Autologous stem cell transplant, allogeneic stem cell transplant, targeted therapy and maintenance therapy are some of the treatment options that are available for relapsed multiple myeloma. The most important thing for patients is to keep themselves well informed. With proper preparation and treatment, the situation can be controlled.

Ski bags are an essential part of travel equipment if you happen to be an avid skier. In case you do travel a lot, the hard case ski bag could prove to be the best one for you. Space is an important factor when it comes to choosing best ski bags after all, if you find a good ski bag that provides enough space for your bulky, heavy, voluminous ski boots, you should go for them. However, space is just one good feature. Listed below are the features that you should for in a ski bags Wheels: If you feel that your ski bag is heavy and you opt for the wheeled ones, the best idea would be to pick one with the larger wheels, which are easier to maneuver. Some of the better-wheeled ski bags along with the snowboard bags use 'Inline Skate Wheels,' which gives the best performance when it comes to maneuvering. Most of the top-quality bags use different styles of large sized (heavy tread) wheels to assist travelers to travel in snowy parking lots. Exterior Compression Straps: Two nylon straps mainly synchronize the movement of the skis inside. In addition to this, if the skis are much smaller than the bag, you can easily fold the extra fabric as well as tie it up with the nylon straps which run around each end of the bag. Interior Gear Straps: These straps are manufactured with nylon. The interior straps fix the gears with your bag, which is responsible and helpful for keeping many skis inside. These straps are excellent to carry numerous pairs of snowboards or skis, as it allows you to secure the gear inside the bag so that it doesn't constantly move during transport. Padded Straps: These padded straps protect your skis from unnecessary harm as well as bumps that come along the way. These padded straps are present in the double ski as well as snowboard bags. Pockets: While pockets have been the most interesting feature that has been added, they have also been the most useful ones. You can keep skiing necessities in the pockets, such as watches, goggles, etc. There are several larger 'ski' as well as 'snowboard bags' that arrive with several pockets to store the gear. Likewise, these pockets have a great place which allows you to store waxing kits as well. To maximize your travel space, you can keep your extra gears in your ski bag.

You need to prepare beforehand to file your tax returns around the end of every financial year. Suppose if you are busy and do not have much time you can request a six-month filing extension by submitting the right form to the internal revenue service. Form 4868 is the application for tax extension of time to file US individual income tax return. Requesting an extension is not a tedious task it can easily don't electronically or on paper. Electronic filing E-file is the electronic filing system of IRS which lets you send in tax forms including form 4868 straight to the IRS computers. By filing this form 4868 electronically through IRS e-file from your personal computer or with a help of tax professionals who uses e-file, the taxpayers can help themselves by getting an extension of time to file their tax returns. The IRS would notify you by sending an electronic acknowledgment which you can file along with your tax records. If you earn around $64,000 as an adjusted gross income you can use the brand name software at no cost from the free file. The taxpayers are benefited largely by this free file service with e-file options and free federal tax preparations. There is a tie-up between IRS and commercial tax software companies which offer fillable form tools for those who get a gross income above $64,000. Filing my mail Filing by mail is a substitute for electronic filing. You can also get the form 4868 in the paper version which can be downloaded from the IRS websites, if not you can also request for the form to be mailed to you by filling out an order form on the IRS website. Alternatively, you can also call to the IRS to apply for a form. But if you are a taxpayer who falls on a fiscal year it becomes a necessity to file form 4868 in paper form. Extension time from state levels Every state has its own rules and regulations for tax extensions. While some may offer a six-month period of extension to all taxpayers uniformly and others have to request for an extension of time by filing a specific form on or before your return's original due date. In certain states, the tax is never imposed hence you file neither a return nor an extension request. You can generate the form using commercial tax preparation software or it could be easily found in the state jurisdiction's website. As per the rules of the state authorities you can extend more time only to file your returns and not to pay your taxes. To avoid penalties and interest you can pay a sum that you might owe and present it as a payment to the tax powers.

Printers and scanners are the most widely used devices to print and make copies. There are various printers such as inkjet printers, laser printers, and thermal printers. These are some of the laser printers. HP LaserJet Pro M477fdw Wireless Color Laser Printer is a multifunctional device which functions as a printer, scanner, copier, and fax machine. This printer helps in creating professional-quality color documents and delivers faster two side printing. This printer consumes lesser energy and can easily access and share resources with other devices in Ethernet and wireless networking. This printer can be connected to the internet through USB 2.0 port or through built-in Wi-Fi.  This printer can print the black as well as color copies at an amazing speed of 28 pages. This printer prints at a resolution of 600x600 dpi for both black and color copies. This printer saves the energy by printing on the two sides of the paper automatically. This printer acts as a flatbed scanner which can scan an area of 8.5"x11.7" with 48-bit color with a resolution of 1200x1200 dpi. This printer/scanner has the ability to reproduce the exact colors and large documents. This printer can fax up to 400 pages with the help of fax memory which is very much useful in offices and corporate companies. This printer can copy up to 28 ppm in black and 28 ppm in color. This printer/scanner can copy at a resolution of 600x600 dpi in color and black. This printer comes with a 50 sheet multi-purpose tray and automatic document feeder which helps in copying, scanning, faxing multiple pages with great ease and comfort. This printer comes with 4.3" intuitive touchscreen color graphics display and  256 MB built-in memory for incredible printing, scanning, copying and  256MB built-in memory Another laser printer is the Brother MFC-L5850DW Monochrome Laser All-In-One Printer/Copier/Scanner/Fax machine. This monochrome laser printer is multi-functional and can be used at the office or small work areas.  This printer comes with 3.7" color touchscreen display which helps in faster printing and copying. this printer can print/copy at a speed of 42 pages per minute both in black and white at a resolution of 1200x600 dpi. This printer can print at the rate of 50,000 pages per month which is really incredible.  This printer can color scan at a 70-page capacity and the auto document feeder helps in two-sided color scanning. This printer takes less time to refill the paper which saves a lot of time. This printer comes with a 300 sheet capacity which can be expanded to1,340 sheets. This printer/scanner can print from a mobile device using the AirPrint, Google Cloud Print, Brother iPrint&scan or Wi-fi direct. This printer has advanced features such as network user authentication which protects against unauthorized access. The wireless networking helps in printing and scanning from mobile devices in a wireless network. Another printer is the Brother Business Wireless Color Laser All-in-One Printer/Scanner/Copier/Fax machine MFC-L8900CDW. This printer is multi-functional which has many facilities like the automatic duplex printing, single-pass copy, scan, and fax capabilities. This printer can deliver high-quality output at a lower cost. This printer can print up to 33 pages per minute and can print 6,500 pages for one cartridge toner. This printer can scan at a capacity of 70-pages and comes with a 5-inch color touchscreen display which helps in easy menu navigation. This printer comes with a 250 sheet paper tray for letter/legal paper handles. This printer can be expanded to a capacity of 1300 sheets. This printer can be connected through built-in gigabit Ethernet or through wireless networking. This printer can print comes with large document glass for scanning/copying documents to print legal size and other bound material. This printer comes with advanced security features which can protect sensitive documents and helps in restricting the use of the printer per user or per group basis. These printers are available in retail stores or online websites such as officedpet.com at lower prices than the original cost which makes them value for money products.