A rare genetic condition, spinal muscular atrophy (SMA), affects one in six to ten thousand people. This condition causes an impairment in the individual's ability to control their muscle movement. The main cause of the condition is a gene mutation; however, the symptoms, onset, and progress of the condition can be significantly different in every case. This is why SMA is broadly divided into four different types to provide information for physicians. Following is information about the four types of SMA for physicians: Type 1 SMA- Type 1 SMA is also referred to as infantile-onset SMA or Werdnig-Hoffmann disease. The main cause of this condition is possession of only two copies of the SMN2 gene. This is the most common type of SMA and more than half the patients are diagnosed with the type 1 SMA. The symptoms for this type start within the first six months of birth. They include weak cries; difficulty in moving, swallowing, or breathing; hypotonia (weak or floppy arms and legs); and inability to sit without support. Babies usually did not survive type 1 SMA, but with more information on SMA for physicians with new research and technology, a drastic change in the survival rate has been noted. Type 2 SMA- This type of SMA is also known as the intermediate SMA and, in most cases, individuals with type 2 SMA have a minimum of SMN2 genes. The symptoms start a little later when the baby is 7 to 18 months old. They can be less severe than type 1 in some cases. Symptoms include difficulty in standing, weak arms and legs, scoliosis (curved spine), coughing, and tremors in the fingers and hands. This type of the condition can reduce the life expectancy, but a large number of people with type 2 SMA survive into adulthood. Type 3 SMA- It is also known as the late-onset SMA or mild SMA. The symptoms for this condition are specific. Individuals with this condition have four to eight SMN2 genes. The symptoms begin after 18 months of age and are usually diagnosed at the age of 3. In some cases, the symptoms can be delayed and can only be encountered in the early parts of adulthood. They include difficulty in getting up from seated positions, balance issues, scoliosis, and a difficulty in climbing steps or running. This type does not alter the life expectancy, but it comes with the risk of obesity. Type 4 SMA- Also referred to as the adult-onset SMA, individuals with this condition have four to eight SMN2 genes. This is the least common type of all four types. Symptoms for this type usually occur post 35 years of age. They include weakness in the hands and feet, difficulty in walking, and shaking or twitching of muscles.

Getting new refrigerator for your home? Want to make your purchases cost-effective as well as functional! Well, then you need to make your purchase carefully. Just getting any refrigerator in your budget will not serve the purpose. If you want to get the best value for the money, you need to purchase from reputed brands such as LG or Whirlpool. These brands have received a huge popularity in the last few years and investing in LG refrigerators, or Whirlpool refrigerators can be advantageous for you. When you are purchasing LG or Whirlpool refrigerators, you can be assured of receiving the best value for your money, as these brands keep themselves updated with the latest introductions in the field. The research and development team of these brands keep themselves updated with the changing tastes of customers, and so you can expect the best functional piece from them. Getting Whirlpool refrigerators for your home can also assure you the best after sales service at a moderate price. When you are getting Whirlpool refrigerators, you can easily get free installation as well as free servicing from the company for a period. You can even book servicing appointment after the period by just paying a few dollars. The best part is, it will not be difficult for you to find any spare parts for LG or Whirlpool refrigerators and you can get them easily replaced when needed. Whirlpool refrigerators might be a bit expensive than the ordinary brands, yet they provide you the best value for your money by offering durable goods. Once you get these refrigerators home, you can be assured of receiving uninterrupted services for years. Most of the Whirlpool refrigerators or LG refrigerator comes with power saving feature. That means you will not have to worry about hefty electricity bills at the end of the month. Nowadays, refrigerators of almost all reputed brands are available online. All you need is to search for the right type of refrigerator for your home and get the order placed. When placing an order for refrigerator online, you can check the sites, which offer free delivery so that you can save a few dollars extra.

The role of the body's immune system is to fight bacteria and other disease-causing germs from causing an infection. However, when some foreign substance comes in contact with the body, the allergic part of the immune system reacts in an exaggerated manner. People who are predisposed to allergies are called allergic or atopic. For a non-allergic person, the immune system will have no reaction, but for an allergic individual, the immune system will send a response when it identifies the foreign bodies. Allergens are the substances that produce allergies. Medications, food, pollen, dust, animal proteins and molds are some of the common allergens. The immune system of the body gives a response through an antibody (Immunoglobulin E) the moment it comes in contact with an allergen.

Types of Allergies

The following are the various types of allergies:

• Dust allergy: Pollution and dust particles fill the air we breathe and can cause an allergic reaction in some individuals.
• Pet allergy: Allergy from pets like cats and dogs are common in people who own a pet. Their skin, fur and saliva have allergens, which cause an individual to suffer from allergies.
• Food allergy: Eggs, milk, peanuts, shellfish and soy are some of the allergy-producing food, which can cause mild to severe allergies to a person. In certain instances, the reaction can be extreme and require medical interventions.
• Eye allergy: Conjunctivitis is a form of inflammation caused by contact with allergens such as pollen.
• Skin allergy: Eczema is one of the most common types of skin allergies, causing inflammation and itchiness. This is usually prevalent among young children.
• Allergic rhinitis: Also known as hay fever, this occurs from pollens or molds present in the environment.
• Latex allergy: It is a type of allergy that can have severe reactions. It is better to avoid exposure or contact with latex.
• Drug allergy: If an individual develops rashes or hives after having a particular medicine, then it is said to be a drug allergy.
• Mold allergy: Molds live everywhere, from the garden to inside the house, especially in the bathroom and cause allergy.

Allergy symptoms

The immune system releases a chemical known as histamine to counteract with dangerous substances. The secretion of this chemical causes a variety of symptoms like skin rash, runny nose, sneezing, nausea, fever and even diarrhea. Anaphylaxis is the most severe reaction to allergy, which can be fatal.

Diagnosis and treatment

There are two types of tests to determine the type of allergy:

• Puncture/prick: A diluted allergen is applied to the surface of the skin by pricking with a needle.
• Intradermal: A diluted allergen is injected below the surface of the skin with a thin needle.

If the prick test is negative, then intradermal are used. A red itchy bump with a flare around it indicates that the body has an allergen. If the wheal and the flare are large, the case is sensitive. The doctor would review the history of the patient, analyse the skin test report and prescribe medication accordingly.

Are you looking for kitchen sinks? Or shower enclosures? Or cement and cladding materials? Whatever it is you need for carrying out home improvements is available in Wickes, a home improvement retailer and garden center. Founded by Henry Dunn Wickes and his brother as a local timber enterprise in Michigan, United States, in 1854 as a one-stop-shop selling a full range of construction products at prices often lower than local yards and merchants to builders , Wickes, even today, is the place to go for the right deals and save your money, especially with their Price Promise - that is, if you find an equivalent product cheaper locally, they will match it with that price! A confident bet undeniably! Here is a brief list of what is offered in Wickes:

• Kitchen- Appliances, sinks, worktops, taps
• Bathroom- Cisterns, counter tops, showers, towel radiators
• Building materials- Insulation sheets, skirting boards, MDF sheets, timber
• Gardens and landscaping- Lawn mowers, trellis & Screenings, compost and pesticides
• Doors and windows- Handles and knobs, folding/ sliding/ glazed doors, hinges and padlocks
• Flooring and tiles- Wood/ vinyl/ mosaic floors, carpets, trims, grout, window beading, roof sheets, plaster boards, pergola, deck boards;
• Heating and pumping- Universal radiators, soldering equipment, washers and rings, basin and bath plugs, copper fittings;
• Paint and interiors- Undercoat and primer, decorative mouldings, wallpapers, handrails;
• Electrical and safety- Cables, alarms, bulbs, ducts, switches, smart home sensors;
• Tools and workwear- Drills, scruffs, ladders, hammers, wheel barrow, tapes, oil; nails, adhesives, screws, sealants, fillers;
• Others- CCTVs, letter boxes, drawers slides, fire and gas safety alarms and a whole houseful more of accessories and fittings.

With a model kitchen/bath, an inspirational gallery, showrooms, free design consultations and brochures, ideas, buying guides and How-To notes and videos, Wickes is the place to go to for a practical, find-all store. Totally committed to reducing their impact on the environment, Wickes have taken steps to improve energy efficiency and reduce waste from these stores, offices and distribution centers, while at the same time, making a sincere continuous effort to also source materials from environmentally responsible suppliers and manufacturers. Wickes also sells products such as insulation, thermostatic radiator valves, composters and water butts that help make environmental improvements around your home. Their customer services provides services pertaining to online, store and general inquiries like store timings, locations, emails and telephone numbers; delivery information - free click and collect in an hour option, same day/next day/chosen day delivery package, bulky item deliveries are all available for customers who wisely choose Wickes to shop for their needs. Do it right. Choose Wickes.

If you missed the Black Friday deals, you get another chance on Cyber Monday to save money on all kinds of products, especially electronics. If you are looking for laptops, Cyber Monday deals cover every gadget—Windows laptop, Chromebook, and even MacBook. Laptops are extremely crucial devices for your everyday work and home requirements. So, based on past years’ deals, here are some of the best Cyber Monday laptops offers you can expect.

1. Dell Inspiron 16 Plus The Dell Inspiron 16 Plus features a 3K display, 11^th Gen Intel Core i7, RTX 3060 GPU, 16 GB RAM, and a 1 TB SSD. Last year, shoppers got discounts on the Dell website using the code SAVE15 on the laptop’s regular price of $1,232.49.
2. Asus VivoBook Pro 14 OLED Retailing at $749, the Asus VivoBook Pro 14 could sell for $599 this Cyber Monday. This laptop has a brilliant 14-inch OLED display and comes with a built-in number pad on the touchpad. Other specs of this laptop include 11^th Gen Intel Core i5, 8 GB RAM, and a 256 GB SSD.
3. Microsoft Surface Pro 7 This is a solid laptop cum tablet that comes with an i3 processor, 8 GB RAM, and 128 GB SSD. At Walmart last year, the Surface Pro 7 carried a discount of $400, selling for $599 with the original price being $999.
4. MacBook Air M1 You could save $70 on the MacBook Air featuring Apple’s new and powerful M1 CPU. This premium, thin, and lightweight laptop comes with a 13-3-inch Retina display, 8 GB RAM, and a 256 SSD. It was on sale for $929 last year against its regular price of $999.
5. Samsung Galaxy Book Pro 360 This laptop comes with solid specifications and is ideal for work and entertainment. Samsung’s 2-in-1 packs a 13.3-in AMOLED touchscreen, an i7 processor, 8 GB RAM, and 256 SSD. Retailing at $1199, the Samsung Galaxy Book Pro 360 was available for $809 on the Samsung website.
6. Lenovo Legion 5 If you are looking for a gaming laptop with a large screen, then the Lenovo Legion 5 is a great option. The 17.3-inch laptop was on sale for $1199 at a price drop of $200. Other specs of this gaming laptop include AMD Ryzen 7 5800H Octa-Core CPU, Nvidia GeForce RTX 3060 6GB CPU, 16 GB RAM, and 256 GB SSD.
7. HP Envy Powered by an Intel Core i5 processor, this laptop that usually retails for $949.99 was available for $649.99 at HP during last year’s sale. This laptop comes with a full HD 13.3-inch display, 8GB RAM, and 256 GB SSD, and it can also be customized.
8. Acer Swift 5 Acer Swift 5 has a 14-in display and comes with an 11th-generation Intel Core i7 processor, 16 GB RAM, and 1 TB SSD. You can get this premium lightweight laptop without breaking the bank. For Cyber Monday, this laptop previously carried a discount of $310 on its regular price of $1,300.
9. Google Pixelbook Go Google Pixelbook Go is one of the best lightweight Chromebook laptops. With a brilliant 13.3-inch HD touchscreen display, this laptop also has an Intel Core i5 processor, 8 GB RAM, and 128 GB SSD. Amazon offered this Chromebook for $722 at a $127 discount.
10. Razer Book 13 Featuring an 11th-generation Intel Core i7 processor, this 13-inch laptop is perfect for your gaming needs. The laptop has a vibrant 4K touchscreen display and comes with 16 GB RAM and 512 SSD. You could get $200 off its regular price of $1,700.

Brands could offer last year’s deals or similar discounts on their laptops. So, you should check out different sales, and based on previous Cyber Monday offers, be ready with a list of online sellers and laptops.

The kitchen is an important part of the home and under cabinet range hoods add to the beauty of your kitchen.There is a range of under cabinet range hood which can make your kitchen look elegant and organized. Wall mount range hoods: The under cabinet range hood also comes with wall mount option. These hoods are available in 30, and 36'' width and have a brushed stainless steel touch which adds to its elegance. If you are looking for flexible sizing in these, it could be a great option to consider since these have adjustable chimneys. It also has a large filtration area and is dishwasher safe owing to the aluminum cassette filters. It also has a three-speed fan which can be operated with the help of touch controls. Island range hoods: This under cabinet range hood comes with stainless steel frame and has 4 level speeds with dedicated timer function. The control in island range hoods is touched sensitive and has a blue LED lighting which makes operating the island range hood extremely easy. The filters in island range hoods are dishwasher safe and since the filters are made out of Aluminum, these last long. The island range hood is made from a brushed stainless steel material and has a tempered glass canopy. The hood is also popular owing to the reason that it comes with a 30-hour cleaning reminder and has a delayed power auto shut off. In case, you are not satisfied with the performance of your island range hood; it also comes with a 1-year warranty on the parts which can be replaced in case of any eventuality. Auto clean stainless steel range hood: This is considered among heavy-duty range hood for those who wish to take up cooking at a professional level. Equipped with exhaust duct, the auto clean stainless steel range hood is popular among under cabinet range hoods. It also has twin motors which revolve in different directions and thus reduce the amount of noise which is produced. This steel range hood has a switch control panel which is electronically operated and does not have any filters. The absence of filters in this under cabinet range hood helps in enhancement of air quality which is delivered.It also has 8 W of input power which helps the auto cleaner to be operated properly. However, when you decide to install any of these under cabinet range hoods, it should be ensured that technically competent people are deployed for this task, else it can be dangerous. Most of these range hoods come with a five-year limited warranty, and you can get the same repaired or replaced if you are not happy with the delivery of the service or the quality of the product.