What is Parkinson's disease? Parkinson's disease is a neurodegenerative brain disorder that affects the motor movements of the body. People diagnosed with this disease experience stiffness and poor mental ability. It develops gradually in the body and remains for years until death. Causes of Parkinson's disease Dopamine is an important neurotransmitter present in the brain. When this neurotransmitter isn't produced, it affects the motor functioning of the body. The neurotransmitter present in the neuron stays in a particular area called the substantia nigra of the brain. Dopamine sends messages between the substantia nigra and other parts of the brain to control the motor functioning of the body and is responsible for smooth muscle movements. When 80% of the dopamine cells are damaged, it leads to Parkinson's disease, also known as neurodegeneration. Sometimes this disease is considered to be genetic but usually, it doesn't run in the family. Symptoms of Parkinson's disease Symptoms progress slowly in one's body. It usually starts from one side of the body and gradually spreads throughout. The progress also depends from person to person. Exposure to certain chemicals in the environment is also considered to be a factor responsible for Parkinson's disease. Early signs of Parkinson's disease Some of the early signs and symptoms include:

• Twitching/ shaking of hands, legs or arms
• Trouble walking
• Regular constipation
• Stooping/hunching back
• Masked face
• Dizziness
• Stiffness of legs, arms, and trunk
• Slow motor activity
• Improper balance and coordination
• Loss of smell
• Hyposmia
• Sleeping disorders

Over the years, the symptoms of Parkinson's disease worsen, and people diagnosed with this develop a low/blurred voice and face difficulty in talking, walking, and performing daily chores. There are cases where they also develop chewing or swallowing problems and in the worse scenario, it leads to depression. Treatment for Parkinson's disease There are no lab tests for Parkinson's disease. Doctors use the medical history and neurological examinations to diagnose it. Although, there is no complete curable treatment for Parkinson's disease, there are medications which will slow down or control the symptoms. In some cases, doctors may also recommend surgery to regulate certain regions of the brain to control the disease. Parkinson's disease life expectancy Researchers have shown that men are more likely to be affected by Parkinson's than women. Parkinson's usually begins at the age of 60 and sometimes prior to it. Parkinson's disease life expectancy is same as people who don't have the disease. Surgery of some part of the brain, like Deep Brain Stimulation (DBS), can help in certain cases. In this type of surgery, electrodes are implanted surgically in the brain, which sends electrical pulses to stimulate the parts of the brain that control movement.

Are you all geared up for your next vacation? So why not choose a lavish cruise which will be worth spending your money in? Here is a list of a few of the best last-minute cruise deals compiled for you. 7-Night Mediterranean Cruise Starting from Barcelona This Mediterranean cruise starting from Barcelona and returning again to Barcelona has undergone 82% price drop in the last 36 days. Its cost has reduced from $599 per person to $86 per night. These prices are for the cruise only. The ship is Norwegian Epic which can accommodate 4,100 passengers. The main attractions of this ship are The Blue Man Group a unique performance by cobalt colored performers, The Studio Staterooms private lounge for the single traveler and SVEDKA the only ice bar you will find at sea. The ship will halt at Barcelona, Naples, Civitavecchia, Livorno (Pisa, Florence), Cannes, Palma de Mallorca and then back to Barcelona. 7-Night Bermuda Cruise Starting from New York This last minute cruise deal has undergone a price drop of 81%. The cruise ship is Norwegian Breakaway. The cruise is jam-packed with entertainment to the last-minute. The main attractions on board include the ice bar with sculptures featuring the New York City, Sports Complex, Aqua park and a performance of the very famous Broadway hit, Rock of Ages. The ports of call are New York, Royal Naval Dockyard, West End, Bermuda and back to New York. 4-Night Western Caribbean Cruise Starting from Miami Enjoy this exclusive last minute cruise deal with a price drop of 63% where the prices of the interior have dropped from $349 to $87 per night, ocean view from $379 to $95 per night, balcony $409 to $102 per night and suite from $629 to $157 per night. The name of the ship is Carnival Victory and it can accommodate 3,427 passengers. There are numerous onboard activities available like water slides, video arcade, mini, golf and casinos and various mouth-watering dining options like Guy's Burger joint, Steakhouse, Cucina del Capitano, Bonsai Sushi and the Asian kitchen among various others. The ship will depart from Miami heading towards Key West and Cozumel and then return you back to Miami. 7-Night Alaska Cruise Starting from Seattle This cruise deal is sure to be one of the best with 60% price drop in the last week and you will get the opportunity to admire the grandeurs of Norwegian Pearl, which has a passenger capacity of 2,380. Have a wonderful time with unique entertainment options like The Blue Man Group and Cirque Dreams. Relish delicious food from Ocean Blue, Cagney's Le Bistro, The Haven Restaurant, and ModernoChurrascaria. Get an exemplary party experience with Norwegian Pearl at White Hot Party. The ports where it will halt are Seattle, Juneau, Skagway, Cruising Glacier Bay, Ketchikan, Victoria and then back to Seattle. 5-Night Bahamas Cruise Starting from Jacksonville This cruise deal has undergone a 59% price drop in the last 4 days. The price has dropped from $439 per person to as low as $88 per night. You will be experiencing the serene ambiance of Carnival Elation. Enjoy a hot stone massage or simply relax in the sauna. This cruise deal is one of the best to travel with children because of its various programs on board. The ports of halt are Jacksonville, Nassau, Princess Cays and back to Jacksonville.

The importance of taking good care of vintage furniture lies in the fact that it is the best way to maintain its overall look and value for the generations to come. The key factor to preserve vintage furniture is to never use harsh cleaning agents or polishes that you use for modern furniture. If you do so, it would prove to be detrimental for your furniture. Biological changes like insects, environmental changes like humidity and human intervention like polishing are known to affect vintage furniture in worse ways. Read the tips below if you want your vintage furniture to remain in pristine condition: Protection from sunlight: You should never keep your vintage furniture under the sun. The UV light is harmful and would degrade fabrics and wood. Ideally, you should keep vintage furniture in places where direct sunlight cannot enter. Even if there is a chance of direct sunlight entering the spaces where vintage furniture is placed, you must use curtains and blinds to block the same. Buy a dehumidifier or humidifier: There is a high chance of your vintage furniture to shrink or expand when you keep them near fireplaces, air conditioners, and radiators. This would result in sticky or loosen drawers, loosen glue joints and veneers. This is because the furniture gets affected by the amount of moisture in the atmosphere. Thus, any change can result in their contraction or expansion. In order to keep the room temperature at a normal level or constant, you must buy a dehumidifier or a humidifier. Eradicate or isolate pest infestations: Insects are quite infamous for making fabrics, wood, and leather their breeding place. Beetles and termites generally eat their way out along the grain inside of the wood. Cockroaches feed themselves with the build up grease and dirt on the wood surface. It is easy to identify pest infestations as insects leave a trail on the furniture surface of exit holes behind them. Damage caused due to pest infestation is irreversible and irreparable if you do not take care of it when it is still time. Call for a conservator or an exterminator to inspect the vintage furniture as soon as you see any holes. Use suitable polishes: In order to take care of your vintage furniture, apply a thin coat of superior quality paste wax once a year. It protects the surface from dust and moisture for a longer time. Use slightly dampened lint free and soft cloth to keep the furniture dust free. Move the furniture carefully: Moving the furniture needs special care as well. Always move the tables using their legs to prevent the base from getting loose. Remove the shelves and drawers from furniture before moving the furniture. Move chair holding by the seat and never by the arms or back. How do you maintain your vintage furniture pieces?

Sears is one of the oldest chains of departmental stores in the country. This brand is present in hundreds of locations, and it is known to provide household items including kitchen appliances at competitive prices. Like all departmental stores, Sears also has clearance sales from time to time and currently, the Sears appliance sale has the following items on clearance. Polka 3-quart Capacity Slow Cooker – SCR300 There is a substantial discount on this slow cooker in the Sears appliance sale. It has a white and purple polka dot design, which makes it a good fit for any kitchen. This product is currently available at Sears for a price of around $7.20. This slow cooker from Crock-Pot is the perfect choice for families that like slow-cooked recipes. It is ideal for preparing slow roasts, simmering soups, making spaghetti sauces, and so many other dishes that need hours of cooking. In this cooker, the company offers low cook and high cook settings along with a clear glass lid, so that you can keep an eye on your dish. Kenmore Top Freezer Refrigerator Sears is currently selling this 14.5 Cu. Ft. refrigerator from Kenmore for roughly $389.99 in their clearance sale. You can also lease this refrigerator at a price of around $17.55 per week. This refrigerator is available in white and comes with facilities like a frost-free freezer and easy-to-clean glass shelves. Additionally, it has an adjustable cooling system that takes care of the power bill while ensuring that everything inside the fridge stays fresh for longer durations. The enhanced interior lighting and glass shelves help users find things inside the refrigerator, and its small size is ideal for kitchens with space constraints. FlexBrew Single Serve Coffee Maker This kitchen appliance from Hamilton Beach Brands Inc. is priced at around $79 at Sears. This coffee maker grinds coffee beans, and brews ‘K-Cups’ as well. It comes with a programmable timer and a removable water reservoir. This product is easy to use and is apt for small households where morning coffee is a ritual. It has a programmable timer that lets you wake up to a fresh brew of coffee every morning, and the 40 oz water reservoir ensures that you don't have to refill it frequently. This coffee machine has an LED light that informs you about the status of your coffee, and its auto shutoff function turns off the machine if not used for a long time. All the parts are dishwasher safe. If you have been planning to buy any of these products, now is the best time to grab them at the Sears appliances sale.

The process of getting an emergency bail bond can seem extremely overwhelming. An unexpected event in the form of one's or a loved one's arrest is unfortunate and a dark spot to be in. The first thing to do is to make provisions to get out of police custody and bail may be the only way to do so. Whether one is eligible for a bail depends upon the offense and the amount, set by the court, to be paid. One may not be prepared to raise funds for the bail bond process and this is where a bail bonds service steps in. A bail bonds service plays a pivotal role in helping the suspect get out of jail while dealing with the large sum of money that must be paid to the court. The service must be professional and trust-worthy. For those looking to pick a Los Angeles bail bonds service company, it must hold a good reputation while being highly experienced. Here are some factors to consider that will aid in gathering a basic understanding of how the service works in Los Angeles and what can be expected: The process of employing a bail bonds service in Los Angeles Upon selecting the right bail bonds service in Los Angeles, the client must handover all the essential documents of the case to the handler. The bonds service will record essential information pertaining to the personal details of the defendant. These factors help the bail bonds service provider ascertain if he/she would want to undertake the case. In case if the bail bonds service is being rendered and the agreement is signed, the bond is posted, and the defendant is released. The process of hiring a bail bonds service company and having the defendant released can take up several hours or a day or two. The types of bail bonds that a company provides The court issues three types of bail bonds and the same are serviced by bail bonds service companies in Los Angeles. The three important ones include:

• Cash bonds that require one to pay an upfront cost and are commonly used to ensure that the suspect is present during court sessions.
• Surety bonds are one in which the bail bonds service company or agent provides a surety that the payment will be made in the case the accused flees.
• A property bond is no different from a surety bond. However, in this kind of bond, a lien is put on the property by the court.

One must be sure to contact a bail bonds service that provides an all-round service in Los Angeles. This will aid with the need for help during emergency situations. In terms of cost, the general cost will depend upon the regulations and statuses of the area. The key lies in finding one that is adequate and not unfairly discriminatory.

Looking at detailed myeloma information gives us an insight into what it is and how it affects us. Multiple myeloma is a form of blood cancer that develops in the soft tissue part of the bones called plasma cells. These plasma cells, also called white blood cells, are responsible for generating antibodies that are required to fight bacteria, viruses, or fungi in the immune system. While studies and reference material explaining myeloma information cannot point to ways to prevent it, an understanding of its causes and risks will help to a certain extent. Prevention Multiple myeloma is not a preventable condition, but there are certain factors that can increase your risk in developing this disease. Some of these factors are:

• Smoking
• Other forms of cancer, particularly lung cancer
• People with a history of other plasma cell neoplasms or solitary plasmacytoma

Hereditary: Myeloma information and studies prove that multiple myeloma is not hereditary. However, there are some indications that if one of the siblings is suffering from such a condition, then the other sibling is more prone to the condition due to genetic factors, which they may share. Immune system breakdown: Many types of research show that there is a strong connection between the disease and a breakdown of the immune system, which may be triggered due to various reasons as follows

• Many people working in cosmetics industries, agriculturists, those who are exposed to chemicals or pesticides have an increased risk because of exposure to such chemicals.
• Also, those who are constantly exposed to plastics, leather, heavy metals, and petroleum seem to be at an increased risk.
• The other strong risk factor is aging. According to studies, 96% of the cases are diagnosed in people over the age of 45 years and similarly, 63% of the cases occur in people over the age of 65 years.

However, research and studies about myeloma information suggest that these associations or links are not strong enough and that people unconnected to the above can be also diagnosed with these conditions.