The most dangerous kind of skin cancer is known as melanoma. This type of cancerous growth develops as a result of mutations triggered by UV radiation etc. In many cases, these tumors looks like black or brown moles. Melanoma can be treated successfully if it is detected in time. Stage four melanoma is the most advanced stage of this type of cancer. Reaching this stage implies that the cancer cells have spread beyond the lymph nodes and are now attacking the other organs. The organs most commonly affected by melanoma include the lungs, liver, bones, brain and stomach. In stage four melanoma, cancerous moles may start looking and feeling different. As the cancer spreads to the lymph nodes, the nodes begin feeling hard and lumpy. This is because the nodes have begun to get matted together. The tumor may also appear to be thicker than it was earlier. Additionally there may be a break in the skin around the tumor. This may or may not cause bleeding. In addition to checking these physical symptoms your doctor will also conduct a few tests to confirm his diagnosis. These include: • Blood tests to ascertain liver functioning and blood count • Ultrasound scans to see how far the cancer has spread and • A biopsy of the suspected tumor Self-examination is key to when you have been diagnosed with melanoma. The ABCDE of self-examination for stage four melanoma is A- Asymmetry: look out for moles that are asymmetrical and uneven B- Border: look for moles with an irregular or poorly defined border C- Color: look for color variations on the mole D- Diameter: look out for moles that are larger than the size of a pencil eraser E- Evolution: check for changes in shape and size of the mole Stage four melanoma can be treated in a number of different ways. The best way to treat this condition depends on: • The location of the tumor • How far the cancer has spread • The patient's age and overall health • Symptoms being presented • How far the cancer has advanced • The patient's response to treatment There are five standard forms of treatment for melanoma. • Surgery: This is intended to remove the cancerous tumors and lymph nodes affected by it. • Chemotherapy: This involves the use of drugs in a pill form or intravenous form to destroy the cancer cells. • Radiation therapy: This form of treatment uses energy beams for example X rays to destroy the cancer cells. Radiation is often recommended after surgery and can also help relieve melanoma symptoms from other parts of the body. • Immunotherapy: Cancer and a weak immune system have a cyclic relationship. Hence by strengthening the immune system, cancer can also be treated. • Targeted therapy: This involves the use of medication designed according to the vulnerabilities of the cancer cells. In most cases, these drugs are effective only if the cancer cells have genetic mutations. In addition, there are also a number of clinical trials being run to treat melanoma that cannot be removed by surgery.

Cough is mainly a reflex of the body to get rid of throat irritants in the air passage. Cough can be caused due to infections or viral fevers, but can also be one of the symptoms of diseases related to the heart, lung, stomach and the nervous system. Cough symptoms are seen irrespective of age, but the intensity of it can be the one differentiation, for you or the physician to figure the seriousness of it. There are basically two types of cough - acute and chronic. Read along to find out more about them and their differences, causes and possible treatments. Acute cough: It is a common cough due to seasonal allergies or hay fever.

• Causes: It occurs along with other symptoms like cold, fever, shortness of breath and lasts for less than three weeks. It can be the initial signs of flu, tuberculosis, pneumonia or any other respiratory illnesses.
• Treatment: These cough symptoms can be treated easily, with either home remedies or allergy medications. But a visit to a doctor is advisable as it will help you diagnose if there are any other deeper issues.

Chronic cough: It is a more serious condition where the need for medical attention is a must. This lasts for more than eight weeks.

• Causes: The chronic cough symptoms are mainly caused due to smoking tobacco products, which can also cause chronic bronchitis. The other causes are asthma, gastrointestinal reflux disease or post-natal drip. It can also be due to the side effects of certain medications or long-lasting infections.
• Treatment: In this case, medical help is the most recommended form. Also quitting smoking and avoiding exposure to allergens and irritants can assist in relieving cough symptoms.

Both acute and chronic cough need to be treated with the right medication. Both conditions should not be ignored, as it may lead to further complications. Lifestyle changes are also beneficial, which would mean a balanced diet and regular physical exercises. A thorough check up by a physician is also recommended.

Today, with the help of mobile technology a number of American businesses are able to go virtual with much ease. This means loads of savings on rents, bills, mortgages, maintenance costs, etc. However, while you are saving quite a bit of bucks on these overheads, compromise on customer service is a total no-no. This means that whether virtual or not, customers would expect top-notch service from your business. And why not? After all, the customer is king. The first impression is, more often than not, the last impression, and sometimes, that all starts with a simple “hello.” This is where the importance of a virtual office phone answering service comes into play. Also known as a virtual receptionist (VR), this service is nothing but the job of a telephone operator that has been outsourced. So, while you are operating from anywhere in the world, your VR answers the phone ever so politely, making customers believe that it is your office premises they have made a call to. What does a virtual answering service do? Your virtual office phone answering service performs a number of tasks like answering calls, taking messages, virtual phone number forwarding, handling emergency calls, etc. Apart from this, most VR’s also have access to the Internet that would help solve your customer’s queries in real time and even answer FAQ’s should they have access to your company’s database. But how does a VR help you reduce business costs? A virtual office phone answering service helps reduce your business costs by saving on the salary you would normally pay a receptionist. A full-time receptionist would easily cost you anywhere between USD 10 to USD 20 for 160 hours of work, i.e. 4 weeks of work, broken down into 8 hours per day. A VR would cost you barely 12 cents to a dollar for 720 hours of work per month (Yes, a virtual office phone answering service operates 24/7!). So, no matter how big or small your business is, hiring a VR can certainly help you save some big bucks!

Located across 1249 cities, Target is one of the most popular stores to find anything and everything. California has the highest number with 278 stores; thus, 19.03% of Target stores are there in California. Target stores remain open for extra hours during the holiday season to accommodate the last minute shoppers. Target stores stock products from nearly every brand including Wild Fable, Heyday, Original Use, A New Day, Prologue, Universal Thread, Who What Wear, Xhilaration, C9 Champion, Ava and Viv, Knox Rose, Cloud Island, Pillowfort, Smith and Hawken, Room Essential, Threshold, Archer Farms, Market Pantry, and, Sutton and Dodge. Here are some of the popular categories of products available at Target • Clothes, shoes, and accessories: This includes the latest trends in clothes and accessories for everyone of all ages and genders. • Baby and kids: This includes baby clothes and shoes, girls clothes and shoes, and boy’s clothes and shoes. • Home and patio: This includes furniture, patio and garden furniture, home decor, bedding, lamps and lighting, rugs, luggage, storage and organization items, home appliances, and home improvement. • Electronics and office: This category includes TV and home theatre, cell phones, headphones, cameras and camcorders, drones, Wi-Fi and networking, and STEM items. • Toys and video games: This includes toys, video games, and books. • Sports fitness and outdoor: This includes bikes, exercise and fitness, camping and outdoors, and sports and outdoors items. • Grocery, household, and pets: This category includes grocery items, pet food and essential, and household items. • Beauty and health: This includes makeup, haircare, men and women’s grooming products, first aid, and nutrition and weight loss products. Among these categories, some are more popular than others among customers at Target. Here are 5 popular things to buy at a Target store.

• Toys: Target stores are the best choice to buy toys as they provide best offers on these. Target offers coupon codes which gives one of the best discounts on branded products. Target provides the best deals or offers during the holiday season in the months of November and December.
• Groceries: These are the second most popular thing to buy at Target stores. Target stock every grocery item across various brands. One of the well-known offers is $10 off on a $50 purchase. Buying groceries at Target is quite a money-saving experience.
• Home Decor: You can get the best home decor and furniture in a Target store; they offer sale codes for home decor and furniture. You will often get $5 off coupons for $50 purchases.
• Video Games and Bluray: These are the best deal products at Target; you get many good deals and offers such as Buy Two Get One Free on many products.
• Household Essentials: Target store is the best option to buy household essentials. The store offers $5 and $10 gift cards for buying certain items. They also offer free shipping.

Bladder cancer is considered as the most common types of cancer and is likely to affect men more than women. Recently, the Food and Drug Administration (FDA) approved the use of Nivolumab for the treatment of patients who have bladder cancer. The combination of Nivolumab and Ipilimumab was evaluated in an appearance I clinical trial. In a recent research, 41 patients were treated with a Nivolumab 1mg/kg plus Ipilimumab 3mg/kg dose, out of which doctors got few positive and good results. Nivolumab is used for the treatment of metastatic bladder cancer among patients whose disease has gotten worse. The FDA approval given to use Nivolumab for the treatment of metastatic bladder cancer was on the basis of the results of Nivolumab clinical trial, which gave positive results. Nivolumab clinical trial was done on 270 patients who were suffering from advanced or metastatic bladder cancer that had worsened over time. 19% of these patients who received Nivolumab had tumor shrinkage for a median of 10.3 months. Out of 53 patients who had tumor shrinkage, 7 patients had complete tumor shrinkage and 46 patients who had partial tumor shrinkage. Nivolumab functions by releasing a protein called Pd-1 on cancer-fighting immune cells called T cells. Once Nivolumab releases PD-1 protein, T cells can destroy the cancer cells. Implications of Nivolumab As there were few options available for treatment of metastatic bladder cancer, doctors started using Nivolumab soon after Nivolumab clinical trial results were approved by FDA. In contrast to typical short-lived responses with cancer therapy in solid metastatic tumors, many responses induced by Nivolumab appear persistent. These persistent results only increased the use of Nivolumab for people who have metastatic bladder cancer. Note of caution If a patient is or was on some prescribed drug or has used some herbal products, then he/she must tell this to the doctor before using Nivolumab. Although Nivolumab clinical trial results are positive and FDA-approved, there are many drugs and over-the-counter medicines, which can interact with Nivolumab and deteriorate the situation.

From getting discounts on your meal to getting free cab rides or to even getting a cheaper haircut, great clip coupons can come in handy. Although these coupons or vouchers might be a bit annoying, advertised everywhere from the the TV to your Facebook page, they provide a number of benefits. 3 Reasons You Shouldn't Ignore Using That Coupon The Incredible Discounts You can save a lot of money if you choose and spend your clip coupons wisely. A lot of people spend numerous hours on the internet completing surveys, looking for ways to win coupons in bulk, so that they can cash in all at once, be it at the grocery store or at the movies. Great clip coupons and promo codes are super fun ways to save money. Over time, you become a smart shopper always looking for discounts and other ways to cut costs. The Endorphin Rush Although this may not be true for many, getting things for free does create that euphoric feeling in you. If you haven't tried your hand at the coupon game, it's about time you do because science tells us that if you get a reward as a result of little effort, you are bound to become happy. Moreover, you are curious to try out newer and exciting stuff, and this will keep you sharp and stimulated. Incentives To Purchase More This is the actual reason why companies give stuff for free. Using vouchers and coupons allows you to purchase stuff that you usually don't buy, like that new flavor of air freshener or that exotic detergent bar. They act as backup when you run out of these commodities. Buying wisely, you can keep your pantry properly stocked. Here's What You Should Look Out For When Using Coupons: The Dates Nothing's more miserable than having the cashier put you off pointing at the expired dates on your coupons. Develop this habit of setting reminders on your phone or calendar to extinguish your coupons before the deadline. Not redeeming coupons There are times when you are entitled to win coupons as a result of a certain amount of purchase at a supermarket. Unawareness or plain laziness could cost you the opportunity to save up on your grocery bills. There are a few flaws when it comes to using coupons; people tend to overbuy and end up wasting money. Before taking any decision, consider the pros and cons. In this case, the pros clearly outweigh the cons as coupons often give you an advantage when used properly.