Bladder cancer is considered as the most common types of cancer and is likely to affect men more than women. Recently, the Food and Drug Administration (FDA) approved the use of Nivolumab for the treatment of patients who have bladder cancer. The combination of Nivolumab and Ipilimumab was evaluated in an appearance I clinical trial. In a recent research, 41 patients were treated with a Nivolumab 1mg/kg plus Ipilimumab 3mg/kg dose, out of which doctors got few positive and good results. Nivolumab is used for the treatment of metastatic bladder cancer among patients whose disease has gotten worse. The FDA approval given to use Nivolumab for the treatment of metastatic bladder cancer was on the basis of the results of Nivolumab clinical trial, which gave positive results. Nivolumab clinical trial was done on 270 patients who were suffering from advanced or metastatic bladder cancer that had worsened over time. 19% of these patients who received Nivolumab had tumor shrinkage for a median of 10.3 months. Out of 53 patients who had tumor shrinkage, 7 patients had complete tumor shrinkage and 46 patients who had partial tumor shrinkage. Nivolumab functions by releasing a protein called Pd-1 on cancer-fighting immune cells called T cells. Once Nivolumab releases PD-1 protein, T cells can destroy the cancer cells. Implications of Nivolumab As there were few options available for treatment of metastatic bladder cancer, doctors started using Nivolumab soon after Nivolumab clinical trial results were approved by FDA. In contrast to typical short-lived responses with cancer therapy in solid metastatic tumors, many responses induced by Nivolumab appear persistent. These persistent results only increased the use of Nivolumab for people who have metastatic bladder cancer. Note of caution If a patient is or was on some prescribed drug or has used some herbal products, then he/she must tell this to the doctor before using Nivolumab. Although Nivolumab clinical trial results are positive and FDA-approved, there are many drugs and over-the-counter medicines, which can interact with Nivolumab and deteriorate the situation.

Magnetic Resonance Imaging or MRI consists of a hollow machine that uses a powerful magnetic field and radio waves to produce pictures of the internal structure of the body, in this case, knee. Knee MRI scan helps determine pain, weakness, swelling or inflammation in and around the knee joint. MRI scanners do not use ionizing radiation and help to determine if you require surgery. Preparing for Knee MRI Scan

• The doctors might require you to wear a gown or they may allow you to wear loose clothing during the scanning exam which does not contain any metal fasteners.
• Some MRI procedures require you to receive contrast medications intravenously that will help MRI scanner to get detailed images of the internal structure of the knee.
• Your radiologist or technologist might ask you if you have allergies of any kind before fixing a dosage. For people allergic to iodine, gadolinium might be used as a contrast medication. Patient consent is therefore required in such cases.

Working of an MRI scanner The machine uses radio frequency pulses to realign hydrogen atoms present in our body while you are in the scanner. It does not cause any chemical changes in the body. The hydrogen atoms emit different levels of energy that vary according to the different type of body tissue. The scanner captures this energy which helps in generating series of images. These images can be studied from different angles and can diagnose if there is an anomaly in the internal structure. The differentiation of abnormal tissue from the normal ones can be better contrasted using an MRI scan when compared with other scanning techniques. The procedure of a knee MRI scan Depending on the severity of the damage, the knee MRI scan may be performed on outpatients or inpatients. The patient is made to be positioned on a movable examination table. Plastics straps might be used to secure the knee and to maintain its correct posture during imaging. There are small coins inside the machine that send and receive radio waves will be placed near the knee will help in improving the image quality. Depending on the type of exam and the equipment, the entire procedure takes 15 to 45 minutes. Most MRI scans are painless. However, some patients might find it uncomfortable to remain still in the machine due to closed confined space. In such cases, sedation might be arranged for patients with claustrophobic and anxiety issues.

Once a license to practice is received, physicians can set up their own practice. There are physician jobs available in health maintenance organizations, government agencies, clinics, and hospitals. The question is, how to find these jobs? What are the common avenues to look for jobs for physicians? Whether fresh out of a residency program or an experienced one, where does a physician look for a new job? Here are some popular ways to look for physician jobs:

1. Personal and professional referral: This is one of the most common ways to search for a job opportunity for a physician. This method has the highest success rate. This is because referral systems work on the basis of trust. A strong referral ensures that clinches the job. It is necessary to build a good network of fellow physicians who can provide information regarding job openings and also give referrals.
2. Search firm recruiters: Search firm recruiters offer the service of connecting the right candidate to the right employer. Although most cases are hit-and-miss (the job profile does not live up to the qualification and experience expectations), recruiters are relatively good sources of job leads. Also, expert recruiters can do a pretty good job of mapping specialization of a physician to a suitable job vacancy.
3. Medical journal advertisements: Journals of medical societies and associations run classifieds on physician job openings. The ads can be placed by a health organization, an employer or a recruiting firm. Becoming a member of medical societies and associations not only gives access to such journals but also presents the possibility of making a strong network of physicians who can provide referrals.
4. Residency Program Staff: Residency program staff are another good source of leads on a job hunt for physicians. Since residency staff interacts with a lot of people in the medical field, they have up-to-date information regarding various openings and vacancies for physicians of different specializations. Thus, they can provide good referrals.

If you are waking up with a body ache every morning, it might be a sign of discarding your existing mattress and getting a brand new one. Mattresses are one of the most significant parts of our bedroom, mostly because they are accountable for a good sleep. Although different varieties of mattresses are available in the market, currently air mattresses are earning a lot of demand. They are lightweight, easily storable and can be effortlessly maintained for several years. The support system of air-based mattresses consists of adaptable air chambers. Moreover, the topmost layers of these mattress types contain memory foam. Residential airbeds are different from the camping kinds because they contain additional materials such as foams, upholstery, fibers, and pads as a means of providing greater comfort to the users. The appearance of airbeds is similar to traditional beds. The earlier versions of air mattresses were known to cause back aches. However, the latest varieties are designed to provide a higher degree of support and comfort. If you need help in selecting an air mattress that is suitable for you, read up mattress reviews. Such mattress reviews will allow you to narrow down the best air mattress according to quality, budget, and expectations. While perusing through mattress reviews for air beds, ensure to focus on aspects such as the firmness of the different sides of the bedding materials, adjustability according to the requirements of the individuals and spaciousness. Opt for those air beds that provide proper support in addition to conforming to your body frame for securing physical relief and improving the quality of your sleep. You can find reliable mattress reviews on trusted e-commerce sites or consumer forums. Numerous considerations need pondering when you embark on mattress-shopping expeditions. Some factors that come into play such as your bodily conditions and budgetary constraints. Although, make sure that prioritize your health and pick a high-quality air mattress.

When it comes to women's accessories, the choice is varied. A handbag is the most versatile accessory and the right handbag can complement your apparel and looks to a great extent. Now, whether you want to sport a designer label or not, it is always best to choose one that matches your personality and body type. There is a handbag for every occasion: an evening bag, the satchel, the clutch, the baguette bag, and the chic hobo bag. The best way to compare handbags from various design houses based on features and price by online shopping. With e-commerce trending, many design houses have opened up to online sales. If you want to buy a Coach handbag, you can buy from Coach's online store, which offers you a wide selection plus good discounts, along with an easy return policy. Following are the benefits of shopping for handbags online Multitude Of Options When you shop online, what you get to view is an exhaustible list of handbags. So diverse is the collection, that you'll be spoiled for choices. You can navigate specific store websites like coach.com and select from the bag list or choose any online platform like Amazon or eBay and filter your search based on your choice of brands. Suppose you want to buy a clutch bag. Online shopping helps you compare clutch bags across brands. This makes it easy for you to select your bag according to your needs. Fabulous Discounts High end designer bags are quite expensive. You will have to think twice before you decide to splurge. The best part about shopping for handbags online is that you can garner fabulous discounts. There is always an offer that is active and you can indulge in a designer handbag at affordable prices. Online stores do not incur taxes and commissions. So, the price is lower compared to the brick and mortar stores. This gives you good savings plus you get discounts as well. Ease Of Exchange And Refund You have extensively searched online and made your purchase. But, after you take delivery, you find that there is some defect like a non functional zipper or you don't like the color shade. You can always exchange online. The refund process is also quick. Just fill out the return form and put the package through UPS. In a few days, the refund will be credited to you without any issues. Plus you save a lot of time and fuel by shopping online. You can avoid the parking woes as well the long queues at checkout. Online shopping is the in-thing of today. With businesses going the e-commerce way to reach out to customers, you can enjoy the luxury of hassle-free shopping.

Official, unofficial, second-hand and more. There are so many ways in which you can access Apple phones. If you are wondering what is the best way to find reliable iPhone stores, you are at the right place. Purchasing a new phone requires you to first know which brand you want to pick up. However, once you know that you also want to ensure that you buy iPhones from the right place. First thing is to get a phone with the right warranty and price. Whether you are looking to shop for an iPhone 6, iPhone 6s, iPhone 7, iPhone 8, or the latest iPhone X, they are available at different places with their own pricing. Before you hit the iPhone stores, here are a few things you should keep in mind: Make sure you have some money saved. This will help you to invest in a better model if it comes at a slightly higher price than the one you had originally planned. Say if the price of the iPhone 7 has come down because of the launch of the iPhone X or in case of an ongoing promotion you can get the iPhone 7 at a good price, you might move onto that instead of the iPhone 6 or iPhone 6s. Find out the best retailers in your area. Make sure you know all the iPhone stores in your area who will be able to give you the best price for your phone. There are a number of options usually to choose from instead of going to the designer Apple store in your area. If you are looking for a good deal online, you might even find some great options on eBay or Craigslist. In fact, most of the cheapest iPhone deals are available online these days. Look out for a reliable second-hand seller of iPhones to get some great deals. With some research, you will be able to find resellers who enjoy a good reputation. They will be able to recommend the best deals based on what they have so that you enjoy the best from your iPhone. Gazelle is one of the popular retailers of second-hand iPhones that you can choose. They have a 30-point inspection system in place, which ensures reliability. Along with that, their phones are certified so you are sure to find them in good working condition. Swappa is another great iPhone store for a hand-me-down phone. However, they tend to have lesser options than Gazelle. Before you buy the iPhone, ensure that the iPhone stores you consider have options that work with your carrier. This is particularly important if you are buying the iPhone from a private source. Find out if the iPhone you want to buy is locked for the carrier you have since it is difficult to switch carriers with locked phones.