Cancer is a disease that can’t be treated without proper diagnosis and medical care. Cancer cells cause enormous damage to the body, which is irreversible. Recurrent multiple myeloma is a phenomenon when cancer returns after a period of remission. Multiple myeloma doesn’t have any cure, and it is true that patients will certainly relapse at some point; this is why recurrent myeloma is also known as relapsed multiple myeloma (RMM). Scope of Treatment for Relapsed Multiple Myeloma Multiple myeloma doesn’t have any treatment; however,  decoding the DNA has enabled doctors to treat patients with relapsed myeloma. Depending upon the condition and the responsiveness of the patient, there are four ways that can be used for the treatment of RMM.

• DNA Alteration: DNA alteration treatment is used when it is considered that the patient is suffering from t (4, 14) disorder, which involves chromosome translocation. It has been clinically proven that patients with this form of RMM respond well when they are treated with a proteasome inhibitor.
• Progression Free Survival: If a patient has had a positive response to the prior treatments of cancer and the relapse has still occurred, it could be beneficial to opt for progression free survival. In this form of relapsed multiple myeloma treatment, it has been clinically demonstrated that patients with an intermediate risk respond positively if properly retreated.
• Switching Drug Class: Patients who have not reacted positively to their prior treatment of cancer may be asked to opt for the drug switching treatment. Almost 20% of high-risk patients have been better off with this treatment and when consulted with expert oncologists, the outcome can be positive.
• Cytogenetic: This is one of the newest forms of therapy for the treatment of relapsed multiple myeloma. Using this, researchers argue that patients with t (4, 14), del17p or t (14, 16) can be treated better than any other method. However, due to the lack of any evidence, there is no support for this form of treatment.

Treating RMM is certainly a challenge, but if a patient is treated with good care and all the parameters such as age, health, genomic test results are taken into consideration, it can help in curing the relapse.

The Nissan Altima is one of the top selling car models by Nissan. It is a mid-size car which has been produced since 1992. The car received significant acclaim for its features, performance and look. The Nissan Altima has been evolving across five generations. The first four generations were manufactured exclusively in the United States. They were officially sold in North and South America, Australia and the Middle-East. The latest 2017 Nissan Altima 2.5 s model The latest 2017 model of Nissan Altima has great features. The premium exterior design is innovative. It has interesting elements like powerful lines and LED headlights. The well-designed sedan has an appreciable craftsmanship. The exteriors The aerodynamic exterior features of the car are enhanced by active grille shutters. These shutters have 4-cylinder trims that close automatically while speeding on highways. This feature decreases the resistance of the wind, thus boosting the car's efficiency. The hood, the mirrors, and the tail lights have been engineered to boost performance and fuel efficiency. The windows are made of solar glass to shield the interior from harmful UV rays. The interiors One of the best features of the Nissan Altima 2.5 s model's interior is the advanced drive-assist display. It consists of a 4.3 inch LCD screen which displays service warnings, call interactions and other essential information. This well-engineered aspect has sub-features like navigation, messaging and direction settings. Another fine feature is the 5 color display AM/FM/CD audio system. The screen of this feature helps you see what's behind you while you're backing up, by converting into a rearview mirror. The interiors also consist of a convenient USB input to plug in your iPod and other compatible devices. There is also a Bluetooth Hands-free phone system which can stream songs from the music player of your phone. The controls are mounted on the steering wheel. Performance The Nissan Altima 2.5 s model ensures fuel efficiency without compromising on performance. The 179-hp engine is sturdy, fuel-efficient and long-lasting. The car has impressive gas mileage and delivers smooth performance. The Altima gives you a controlled and smooth ride even when you take a corner. The active understeer control responsible for this. The shock absorbers are of top notch quality. The Altima is well-equipped with ZF Sachs which absorbs shock as good as absorbers in luxury cars. The car prioritizes on your safety with its tire pressure monitoring system and stability control features. It comes with a 4-wheel set of 16 inch gunmetal aluminium-alloy wheels. It also has 4 pieces of splash guards and Nissan carpeted trunk and floor mats. These features are the best of what is available in the market today. The Nissan Altima 2017 2.5 s model is a brilliant choice for performance, fuel efficiency, comfort, and appearance.

Whether it’s defrosting, heating, baking, or even cooking, a microwave is an essential kitchen appliance that most of us are unable to do without. According to a census conducted by Energy Information Administration (EIA), a whopping 96 percent of American homes have microwaves. Now that’s huge number, isn’t it? However, one thing that’s important for you to know is that not every American home has the same kind of microwave. While countertop microwaves were yesteryears trend, today technology has brought about a gamut of innovation in the microwave arena.Due to technological advancements, today, apart from counter top microwaves there is a range of other microwaves that exist in the market. A few of these are-Over range microwaves, Built-in microwaves and Drawer style microwaves.To make the best of it, selecting a microwave that specifically suits your needs and fits your budget would be a good idea. Here are few key features of the different microwaves available today that you must know about:

• Countertop Microwaves

The lowest in the price bracket, these microwaves can range anywhere from USD 70 to USD 650, depending on the size. However, the only con to this model is that it ends up taking too much of your kitchen counter space.

• Over range microwaves

Very often referred to as OTRs, over range microwaves are generally installed above your cooktop. And owing to its hood ventilation, it hits two birds with one stone, i.e., it acts as a microwave as well as vents out smoke, steam, and odor from your kitchen. The over range microwaves are great space savers, which is a blessing for the compact kitchens. The price of over range microwaves may vary anywhere from USD 170 to USD 1,300.

• Built-in microwaves

A built-in microwave fits into your kitchen cabinets and comes with a drop-down door, like a conventional oven. This is another great option in case space is a constraint in your kitchen. The price of these microwaves start from about USD 350 and go up to USD 1,500.

• Drawer style microwaves

These microwaves are installed below a countertop or a wall oven and slide out like a drawer, which is why the name. They also come with a child lock feature, that’ll make sure the kids can’t mess around with this one. Drawer style microwaves range anywhere from USD 700 to USD 2,000. To make your microwave experience even more user-friendly, a few features to look for while investing in one are:

• Turntables

Be it over range microwaves, countertop microwaves, or drawer style ones; a turntable is an essential feature you need to look for. Therefore, make sure the microwave you’re buying has an apt enough turntable size to ensure that your food is heated evenly.

• Racks

A microwave with a rack ensures that you have access to more than one layer, thus enabling you to cook multiple things at the same time and saving you some more time than it already does.

• Convection, cooking, and grilling

While most microwaves generally come endowed with a heating feature, do make sure the microwave you invest in has a convection, cooking as well as grilling feature, so that you can do a lot more with this appliance.

• Child lock keys

Any parent would vouch for the importance of this. A child lock feature ensures that your child won’t be able to do much with the microwave once the lock is active.

• Common task keys

This feature makes life a whole lot easier. With keys ranging from time extension to defrosting to auto-cooking, all you need to do is just press a few smart keys, and you’re good to go. Most microwaves also come with shortcut keys that make cooking foods like popcorn, steamed vegetables, bakes, etc. easier. So, what is your favorite microwave among the above listed?

There are endless choices for people to get mobile phone plans in today's wireless industry. Many reputed wireless carriers these days provide the connection with the smartphones. From the barebone tariffs such as Metro PCS, Boost etc., to unlimited expensive plans like AT&T, Sprint, T-Mobile etc., it is all about identifying the best mobile plans and grabbing the best offers. Here are some real facts that would help you land the best phone deal ever. 1. iPhones have up to 40% off deals in many stores and through online websites apart from the retail Apple Stores. AT&T has almost 2000+ stores in the US. By visiting their web page, one will be able to locate the nearby stores. 2. There are many resellers and multiple carrier services, and it is prudent to buy from authorized resellers. Again, it is not mandatory because not every carrier is owned, and as the first priority is for the deals. 3. Best Buy is one such authorized retailer (store and online). Over here, used smartphones feature huge discounts as compared to the original, newly-minted pieces. 4. Target is the big box retailer amongst the many. Here the cell phone deals vary, and the season for deals is mostly June, July, and December. Phones with a service plan from Sprint, Verizon, and AT&T are an easy and great fit for the budget. While they don't sell phones online, it shouldn't be an issue, because there are nearly 1,700 stores spread across the continental US. 5. The world's largest retailer store, Walmart, and its sibling company Sam's Club feature great deals almost every day. For instance, in the year 2010, there was a huge offer on iPhone which no one else had come up with until then they were offering a 16GB iPhone 3GS with a two-year AT&T agreement for $97. So, before committing a deal, it is smart to check the prices at both the stores, and Sam's Clubs usually has more offers. 6. eBay.com and Craigslist are generally the other best online stores to buy latest cell phones. The shopper should check the dealer's rate and purchase smartphones. eBay.com features and stocks both used and new devices, also has offers on free phones and one can choose from many options before investing in any one phone. Used products are generally good enough but most of them will be out of warranty. In the U.S the other brilliant deals for smartphones is to buy phones on contract basis. This is one of the best deals where one can get the latest headset along with a superb service carrier deal, like free calls and data, etc. With the many deals, one would find it hard to pick the exact combination of contract.

Eczema can occur at any age or in any weather condition. It is mostly seen in children. This skin disorder is diagnosed by the appearance of red and itchy skin. About eczema Atopic dermatitis is a common form of eczema. It is a long-lasting skin disorder that can be controlled by regularly moisturizing the affected areas and by avoiding any harsh soap. A doctor might prescribe eczema medications, which can reduce the irritability and redness to a great extent. Eczema treatment options Eczema medications, however, might reduce the symptoms but the condition may persist. Even after all these years of research, doctors have not been able to come up with any permanent solution for eczema. A few common causes of eczema There has again been no solid explanation for this particular disease. There can be many possible causes for eczema, such as the following:

• A healthy skin always retains moisture and stays moisturized and soft, but in the case of eczema, the skin is unable to retain moisture and thus reacts to certain triggers.
• The causes of eczema can be hereditary too. It is seen that children with parents who have a history of atopic dermatitis are most likely to be susceptible to eczema.
• Eczema medications will not be effective if a sibling or a person who already has eczema is in close contact with the child who has eczema. Thus another cause of eczema is not close contact but genes.
• In some children, the occurrence of repeated food allergies can also be a serious cause for eczema.

It is necessary to detect eczema symptoms in the early stages and consult a doctor about eczema medications as soon as possible. The rapid itchy sensation can result in scratching of the area that may turn scaly. This can worsen the condition of the skin.

Buying a used car for a reasonable deal at a good dealer is warranty enough for most buyers as they get to have their pick from a variety of used car deals within a fixed budget. The main advantages of buying from a dealer are:

• Certified pre-owned (CPO) program: Buying from a CPO dealer will ensure that the deal is fail-safe as they are used cars vouched by their own brand and have the perks of warranty and roadside assistance. It is the ultimate deal if a buyer can get a CPO used car as the car would have met certain requirements including the age of the car and mileage as well as passed a series of service checks to be certified.
• A little extra: Dealers like to close their deals and therefore put up catchy offers and discounts to please their customers. Building a rapport with the salesman will also ensure you get some added perks like an extra service or an accessory free of cost.
• Trading: Dealers try to get the best out of the sale and therefore go the extra mile to try and fit your need by even give trade-ins which will help lower the total cost paid for a period of time.
• Negotiation: While the dealer may not readily jump for a drop in price, they would be willing to give their customers the satisfaction of the sale through their discounts and coupons, or get their hands on a used car sale.
• Finance: Money would still be a constraint for used car buyers because they may not have enough credit to get even small sanctions. Dealers’ ties with financial institutions help in guiding the buyer towards picking out a viable option that will enable them to purchase a used car of their choice.

However, there are certain factors that should not be overlooked when buying from a dealer. Pricing is always slightly close to or higher than the actual owner value because that’s how the third-man parties make profits. Since the salesmen are trained professionals, they do not take no for an answer and always try to convince you to pick a bigger deal.