Pickup trucks are known to be much more capable than the usual SUVs or sedans. These trucks are known for their rugged characteristics and salient features. With the perfect blend of design and performance, a large number of people in the country opt for pickup trucks. This comes as no surprise given these vehicles’ transportation capabilities, making them extremely useful for personal as well as professional use. Now, if you are planning on getting one, it is a smart decision. But the next thing that you have to think about is, which one to go for? This is one of the most common questions among a lot of people thinking about which pickup truck to go for. Since pickup trucks sell quite a lot in the USA, every brand is in great competition. So, which one should you go for?  Well, we’ve got a list of the top pickup trucks in 2021, so that you can decide for yourself. Take a look. Chevy Colorado The Chevy Colorado has three individual engines, which include a pacy V-6 as well as a diesel four-cylinder. This pickup truck has a very comfortable driving seat and provides for sturdy handling. Each model of the Chevy Colorado has a state-of-the-art modern infotainment system. This pickup is considered slightly easier to maneuver as compared to its corporate sibling, the GMC Canyon.  Honda Ridgeline Did you know that the Honda Ridgeline is the only Honda vehicle with its cargo bed? Sure, it does not include an optional diesel engine or an off-road-ready model, but it is very spacious compared to a lot of its competitors.  GMC Canyon The GMC Canyon is a much louder choice rather than the Chevy Colorado when it comes to design. Owners can add fancy features such as cooled and heated seats, and cover their pickup in chrome too. It also has three engines, with a V-6 engine as well as a diesel four-cylinder.  Ram 1500 If you think that a pickup truck is only meant to be rugged, the Ram 1500 is sure to blow you away. With its extremely luxurious interiors, split-folding tailgate, built-in cargo-bed bins, and a gigantic 12.0 touchscreen, the Ram 1500 is a great choice. With this pickup, you can get the standard V-6 or opt for the Hemi V-8 that comes with hybrid systems.  Jeep Gladiator The Jeep Gladiator is famous for towing up to 7760 pounds. It has a standard stick-shift transmission and a sturdy V-6 engine. Owners can also opt for a diesel engine with 442 lb-ft. While others on this list might be better alternatives, this would be a great choice too.

Psoriasis is an autoimmune disease characterized by skin cells developing too quickly. Excess skin cells lead to the creation of skin lesions. Every 3 in 10 people who are suffering from psoriasis end up contracting psoriatic arthritis. Psoriatic arthritis is an autoimmune condition characterized by the body attacking healthy joints. This results in inflammation. If not treated, this can cause permanent damage to the joints. You may or may not develop the symptoms of psoriatic arthritis when you first contract the disease and this makes its detection quite difficult. Nevertheless, here a few of the common psoriatic arthritis signs and symptoms and if you are suffering from these symptoms, it is strongly advised to visit a doctor immediately. Signs and symptoms of psoriatic arthritis Swelling – One of the most common symptoms of the disease is the unique swelling it causes in the fingers and toes. A sausage-like swelling appears in the toes and fingers if you are suffering from the condition. Visit a doctor immediately if you are suffering from the same as it is quite painful and can lead to permanent deformities if left untreated. Pain in your feet – While the autoimmune condition causes swelling and joint pain, it is more likely to cause pain in the tendons. Tendons are muscles attached to the bones. Plantar fasciitis and Achilles tendinitis are the two most common tendon affecting conditions associated with psoriasis arthritis. Back pain – Every 2 in 10 people suffering from psoriasis arthritis suffer from joint inflammation between the pelvis and the spine and between the spine’s vertebrae. Morning stiffness – Another common sign and symptom of psoriatic arthritis is the feeling of morning stiffness. You may wake up in the morning and find it hard to move the joints on both sides of the body. You feel stiff and inflexible and you might find it difficult to move. You may also suffer from stiffness when you sit in one place for too long. The condition of psoriatic arthritis symptoms pictures a grim tale if not treated properly. They may or may not appear during the initial contraction of the autoimmune condition. It is of grave importance to visit a doctor immediately after you recognize the psoriatic arthritis signs and symptoms. You can immediately conclude that you are suffering from psoriatic arthritis if you notice a sausage-like swelling in your toes and fingers. This can be extremely painful and can lead to permanent deformities down the line. Therefore, immediate medical consultation is strongly recommended if you notice any of the aforementioned psoriatic arthritis signs and symptoms.

Gone are the days when you had to travel across the world if you wanted to have a business association with people in other countries. The Internet has made life so easy and economical for business owners as now connecting with business associates across borders is quite easy. Video conferencing is one of the most preferred ways to communicate with people. While there are different kinds of video conferencing units available, the one that is making the most rage is a desktop video conferencing system. Typically, an office has a dedicated room for such conferences wherein all the hardware is installed solely to ensure that the meeting goes well. But with the help of a desktop video conferencing system, you don’t need different devices or a separate room for video conferencing with people. All the required hardware and software is installed in the same order that enables you to have a conference without any hassles. One of the best things about these systems is the fact that they are much more economical than setting up a whole new room that is dedicated to organizing video conferences. Earlier, it was necessary to cancel out the office noise and have high-quality speakers installed to make sure that both sides could connect and hold a meeting, but with a superior quality of desktop video conferencing system, you can do so in a small setup. It is a boon for start-ups who wish to expand in other countries but cannot afford to spend a lot of money in connecting with the potential investors in the process. The desktop video conferencing systems have a lot of features that are essential for a good quality call with the counterparts that are across borders. These features are more than just sound quality microphones and screens of HD quality. Some of these features are: touchscreen controls to make changes in the presentation as and when you discuss things, multi-site and multi-conference options for simultaneously deal cracking or pitching in people on the same call from different countries and collaboration tools. All of these features come in handy when you are putting in a lot of effort to get a business running. It also helps in making the company more personal and practical, as you would not have to spend a lot of money to conduct international video conferences.

Buying a ceiling fan is no easy proposition with the number of choices available in the market. However, making a decision would be easier if you keep a few things in mind. Here's a list of features to look for, to determine the right ceiling fan for you. Design: You would want your ceiling fan to complement your home décor. Ensure that the ceiling fan complements your interiors. Antique ceiling fan designs go with traditional and vintage home decor whereas contemporary ceiling fans are more suitable for a modern and transitional space. They feature clean lines, smooth metallic finishes, and are minimalistic. If your interiors are more country, you could opt for straight lines and dark wood finishes of rustic ceiling fans. You can also go for bamboo, natural palm leaf, and rattan blades with distressed wood finishes to complement your bright, tropical interiors. Whatever style or finish you choose, ensure that the rod matches the rest of the fan. Ceiling fan motors: The motor determines the airflow and efficiency of your ceiling fan. DC fan motors are smaller and lighter than standard an AC motor, which allows them to generate higher torque and consume 70 percent less energy. These motors also produce less heat and are virtually silent. Energy Star-rated ceiling fans: Energy Star fans use 15 to 20 percent less energy than standard fans. They come with a minimum 30-year motor warranty and a 1-year component(s) warranty. Energy star fans with lights use 60 percent less energy than standard fans with lights. Airflow: A high airflow operates that your ceiling fan will circulate more air and consumes less energy. These fans are ideal for garages, warehouses, and outdoor spaces. Controls: There are three types of fan controls to choose from. Ceiling Fans with Remote Control can be operated within a 30 to 50-foot range, Handheld remote control ceiling fans are ideal for bedrooms and personal spaces. Wall Control has a range up to 40 feet. It is more suitable for kitchens, dining rooms, and living rooms. Pull Chains offers basic fan control. They add a touch of style to your room; however, they are more practical for spaces with low traffic.

Multiple myeloma is a life-threatening form of blood cancer that starts in the plasma cells of the blood. Myeloma cells accumulate in the bone marrow and slowly degenerate the kidneys and bones of the body. Also called plasma cell myeloma, it is not completely curable. Multiple myeloma is very challenging to treat and is the second most common cancer in the US. Diagnosis occurs when abnormal plasma cells are detected in the bone marrow, and treatment is worked out around controlling organ damage. Immunotherapy is a blanket term that describes various cancer treatment methods. Cancer treatment includes the following:

• Chemotherapy
• Stem cell transplantation
• Radiation
• Medications

Immunotherapy helps in cancer treatment for multiple myeloma patients by focusing on three approaches:

• Reversing tumor mediated immune paralysis: This is done using immunomodulatory drugs and by blocking inhibitory molecules or activating stimulatory molecules.
• By stimulating myeloma specific immune responses: This is done using vaccines that work by stimulating an immune response against tumor specific antigen or substances that the body considers foreign.
• Selectively eliminating the malignant clones: This is done by removing T-cells from the body, thereby genetically engineering and reintroducing them into the body. T-cells start multiplying and then locate and destroy the tumor cells.

The U.S. Food and Drug Department recently approved two drugs for relapsed multiple myeloma treatment. One of the drugs is approved for patients who have already been treated with three therapies. It is a first in class immunotherapy treatment (a monoconal antibody) which works when the patient has become resistant to other treatments or when the disease spreads in a very short span of time. The other drug prods the immune system to attack cancer cells. It is for patients who have undergone one to three therapies earlier. Cancer treatment has potential side effects:

• Infusion related reaction
• Tiredness and difficulty in breathing
• Back pain
• Fever and nausea
• Persistent cough
• Low count of red blood cells, white blood cells, and platelets

Immunotherapy and precision medicine as cancer treatment options work for multiple myeloma patients. A better understanding of causes behind relapse and undertaking new therapies to overcome that resistance is the key to immunotherapy cancer treatment.

Following is a list of the top student loans available: Citizens Bank: For student loans availed from this bank, there is no charge or fee for origination or application of the loan or early repayment of the loan. Another major benefit of this loan is that the interest rate of the loan is reduced by a significant amount if you already have an account with the Citizens Bank. The loans are extended to graduate or undergraduate students and the repayment time of the loans can be 5, 10 or 15 years. Loans are available from the range of $1,000 to $295,000, depending on the degree. CommonBond: The origination fee on this loan is 2% with no application or early repayment fee. Any student dealing with an economic problem after graduation can apply for forbearance to pay back the loan. The rates of the loan may be fixed or variable. Loans are available to students at undergraduate, graduate and MBA levels, with repayment periods of 5, 10 and 15 years. Connext: The loans are usually serviced by Connext, but the ultimate funds come from a group of lenders. There is no fee required to be paid for origination, application or early repayment of loans. Loan values range from $2,000 to $150,000. However, repayment period options for this loan are 10 or 15 years. College Ave: They provide student and parent loans. Interest rates can be reduced by setting up automatic payments with College Ave. Repayment time period can be 8, 10, 12 or 15 years. Another feature of these loans is that College Ave provides the students with an option to make full, interest-only, or flat payments while in school or to defer payments until after graduation. Parent loans can be paid within 5 or 12 years. LendKey: The loans are facilitated by LendKey but funds are provided by community banks. Interest rate can be reduced once the student decides the repayment period and pays 10% of the loan principal or if the student sets up automatic payments. The repayment period is provided up to 10 years.