Multiple myeloma is a life-threatening form of blood cancer that starts in the plasma cells of the blood. Myeloma cells accumulate in the bone marrow and slowly degenerate the kidneys and bones of the body. Also called plasma cell myeloma, it is not completely curable. Multiple myeloma is very challenging to treat and is the second most common cancer in the US. Diagnosis occurs when abnormal plasma cells are detected in the bone marrow, and treatment is worked out around controlling organ damage. Immunotherapy is a blanket term that describes various cancer treatment methods. Cancer treatment includes the following:

• Chemotherapy
• Stem cell transplantation
• Radiation
• Medications

Immunotherapy helps in cancer treatment for multiple myeloma patients by focusing on three approaches:

• Reversing tumor mediated immune paralysis: This is done using immunomodulatory drugs and by blocking inhibitory molecules or activating stimulatory molecules.
• By stimulating myeloma specific immune responses: This is done using vaccines that work by stimulating an immune response against tumor specific antigen or substances that the body considers foreign.
• Selectively eliminating the malignant clones: This is done by removing T-cells from the body, thereby genetically engineering and reintroducing them into the body. T-cells start multiplying and then locate and destroy the tumor cells.

The U.S. Food and Drug Department recently approved two drugs for relapsed multiple myeloma treatment. One of the drugs is approved for patients who have already been treated with three therapies. It is a first in class immunotherapy treatment (a monoconal antibody) which works when the patient has become resistant to other treatments or when the disease spreads in a very short span of time. The other drug prods the immune system to attack cancer cells. It is for patients who have undergone one to three therapies earlier. Cancer treatment has potential side effects:

• Infusion related reaction
• Tiredness and difficulty in breathing
• Back pain
• Fever and nausea
• Persistent cough
• Low count of red blood cells, white blood cells, and platelets

Immunotherapy and precision medicine as cancer treatment options work for multiple myeloma patients. A better understanding of causes behind relapse and undertaking new therapies to overcome that resistance is the key to immunotherapy cancer treatment.

Bipolar disorder, also known as manic depression, is a form of mental health imbalance that causes extreme mood swings in a person. The mood swings can be extremely high as in a feeling of euphoria or full of energy or extremely low as in a feeling of depression and helplessness. They can occur frequently or can occur in rare instances. These cases can occur for a short duration like days and weeks or for a longer duration of months or in some cases years. No bipolar disorder is the same and the patterns vary vastly between every individual. Bipolar disorder has no cure and hence the treatment plans only focus on keeping the condition under control. Let us look at these conditions in detail. Types of bipolar disorder There are several types of bipolar conditions and they usually depend on how frequent or what type of activities you have undergone. Bipolar I disorder: This is a common type and is categorized when a person undergoes one manic episode followed by many depressive instances. For example, a person can get violent and becomes indifferent. Later he/she can fall into depression thinking about the same activity. Bipolar II disorder: This is also a common type where you might be experiencing depressive behavior, but you might not have had a manic episode. For example, a person who always thinks about hurting himself due to depression, but had refrained himself from doing such an activity. Cyclothymic disorder: This condition occurs when you get the conditions in patches or after a gap of time. For example, you might have had an instance in your childhood and the condition gets dormant. Then later on, after many years, the same condition resurfaces. Other types: There are other types of disorders that can be influenced by external factors like drugs, medications, and alcohol/drug abuse. These conditions are relatively easy to cure and can be usually curtailed when the underlying conditions are discontinued. There are certain features of bipolar disorder that you must take note of before taking the treatment approach. These are the mania and hypomania symptoms and episodes. Both of them have the same symptoms. However, mania is even more severe than hypomania and requires immediate hospitalization. The common symptoms can include increased levels of activity and energy, abnormal levels of self-confidence, decreased sleep patterns, and irritability. Also, a person may fall victim for poor decision-making skills over a long period, for example, poor investments, spending spree, unusual levels of unprotected sex/sexual intercourse, etc. Though bipolar disorder can be rare in children, it usually offsets during these periods and remains dormant for the next few years. Usually, a person might experience a trigger mechanism that acts as a buffer in releasing the manic mood swings. The treatment plans can include both medications and physical therapy for the mood swings. The treatment usually succeeds based on how far the individual is willing to go for getting the treatment done. The conditions can be cured optimally if you check with your doctor at any early stage rather than at an advanced stage.

Want to give a style makeover to your home? Looking for some furniture and home improvement accessories that can help you in improving the style statement of your house? Well, then you just cannot keep yourself restricted to the color and designs of your home decor furnishings. You need to buy products from brands, that represent style and elegance. If you are considering patio decoration, you can certainly opt for a popular brand such as Big Lots patio furniture, Hampton Bay patio furniture, Kmart patio furniture, and Home Depot patio doors, as these furnitures represent class and elegance. Use these tips to buy the perfect patio furniture for your home.

• Size and design of the furniture: When you are purchasing a mattress from Big Lots or any other popular home decor brand, you need to pay attention to the size of the furniture where you will use it. If the mattress does not fit the size of your furniture, it will not be possible for you to flaunt the style in the desired way. Thus, all your investment will be wasted.
• Color and theme selection: This is another important factor to be considered when you want to use the mattresses to improve the style statement of your house. Big Lots patio furniture are available in different colors, and you just need to spend some time to find the color that best matches the decor of your patio. Though mattresses mostly remain covered with linens, its recommended to select the style appropriately and remain on the safer side.
• Price and budget: It is quite obvious that you will have to spend a few extra dollars to bring home Big Lots patio furniture. You should not just spend excess than your budget. You should set your budget first and select the price range accordingly. If you do not have a budget to afford these mattresses for the patio and are looking for a cheap deal, you can search for discount coupons. There are several stores, which offer discount deals from time to time and purchasing from them will help you save money without compromising on the style.

Many online stores are now selling Big Lots patio furniture. You just need to select the authentic one and buy one for your home.

Are you a proud owner of Maytag appliances? If you're facing trouble with any of the equipment, here's good news for you. The leading brand of consumer appliances Maytag has made sourcing spare parts easy. Now, you can do repairs anytime with new components that have been made available for longer use. Maytag, which was acquired by Whirlpool in 2006, ensures its loyal customers for a hassle-free appliance parts replacement. Yes, now you can still procure replacement parts when required without any hassle and continue using your favorite Maytag kitchen gadgets.

Fix the trouble With years, your kitchen appliances go through small damages like simple wear and tears that can hamper the usage or looks of the machines. And replacing these broken parts with new ones can be a tedious task. Not from now on, though. Whenever you encounter any problem you can always carry out the repair by purchasing the certified parts for any of your Maytag or Whirlpool equipment with ease. Maytag offers a wide range of consumer appliances such as refrigerators, dishwashers, washers, and dryers to iron, steamers and more. When you face any issue after the purchase, the first step is to examine the machine properly to decide on the part that needs to be replaced. In most of the cases, these can be fixed easily at home by following the instruction manual.

Read the manual For instance, in the case of a dryer unit, if you find the machine has become noisy or leaves a mark on the clothes or takes longer than usual to complete the drying process, then the drum support roller kit might need to be replaced with a new set. In this situation, note down the part number, order the Maytag part either online or by visiting your nearest dealer and complete the repair as per the instruction sheet as it would not be difficult. Similarly, if you find the ice maker in your refrigerator isn't working properly like it does usually or dispenses too much ice or would not start at all, then you will have to replace the ice maker component. You can easily fix this by using the installation instructions available on the internet or by watching DIY videos on the repair that are readily available. Most of the customers have done it and classify the repair work as easy or difficult; both of these require less than half an hour.

Seek help If you find the repair difficult or do not have time for the same, you may contact an authorized service center that will help pinpoint the cause of the trouble and carry out the repair service for you. Maytag parts not only fit the Maytag and Whirlpool machines but can work for several other components from other brands such as Kenmore, Crosley, Hardwick, Amana and more. Just spot the problem and replace the faulty component with a trusted Maytag part for durability.

The next time when you notice a problem with any of your Maytag appliances, observe for the issue for a while to check if the problem repeats. If so, identify the faulty part that is the cause of the trouble, and go for a replacement with the new Maytag parts.

Don’t want to get rid of your sturdy chairs and comfortable sofas but it’s time to give them a new look? The quickest way to do this is to shop for slipcovers. It is a less expensive option than replacing old furniture, and you also get to redecorate within a reasonable budget. While selecting a chair, recliner or sofa slipcovers, you have plenty of choices because they come in different sizes, colors, fabrics, and fit. Some consider slipcovers outdated and sloppy but you should know that the right slipcover can give a facelift to that super comfortable furniture that you are so used to. Slipcovers never go out of style because you can do so much and cover up so much with them. Those faded colors, worn-out fabric, out of shape furniture can look as good as new with the right slipcover. Moreover, you have the option of buying pre-made slipcovers or can get them custom tailored to your choice of fabric and design. If you are wondering how to select the best sofa, chair or recliner slipcover, here are some suggestions. If your sofa’s slipcover is too loose and flowing, it may look shabby, so choosing the right fit for your furniture is important. To do this right, measure your furniture before you set out to buy anything. If you are planning for a ruffle bottom slipcover, don’t forget to measure the width between the bottom of the furniture and the ground. In case your sofa or chair has arms, be particular while measuring the length because custom slipcovers would not be refundable. Stretch slipcovers are a wonderful option because they give a lot of leeways regarding the fit. Fitted slipcovers undoubtedly provide a more flawless and smart look but then they must be tailored with impeccable measurements. The color of the fabric that you choose should ideally complement the rest of your décor style. The most preferred furniture slipcover shades are typically neutral because such shades make the covers easy to blend well with the decor of the rest of the house. Darker shades can add a lot of drama, and vibrant hues can add a cheerful and zesty appeal to your furniture. Finally, it’s for you to choose if you want your sofa’s slipcover to be muted or look bright with exciting colors.

Ever since it was first launched, the Galaxy Note series created quite a stir and quickly grabbed the attention of mobile phone enthusiasts. The series went on to establish a slew of identities among its users and was one of the first devices that led the way to the big screen. It can be said that Samsung has released a new Galaxy Note in every second half of each year, and 2019 is no different. This time, the brand brings the all-new Samsung Galaxy Note 10 and the Galaxy Note 10 Plus. Out of these two powerful models, the Galaxy Note 10 is packed with impressive features and offers the best a cellphone has to offer. The Samsung Galaxy Note 10 and Note 10 Plus are flagship models and are designed with some of the most notable specs. If you are someone who wishes to get your hands on the Samsung Galaxy Note 10, it truly is a great choice. The phone is packed with high levels of productivity and performance, thereby making it highly suitable for people of every profession. Here are 5 factors that make the Samsung Galaxy Note 10 a good buy: Big battery power - We all use our mobile devices on the go, and we need it to be charged for long hours. Samsung regards a powerful battery as the most important feature in its devices -- this is why it has incorporated the intelligent power-saving technology. The Galaxy Note 10 is capable of running for long periods so you can complete all your productive tasks as you keep up with your fast-paced life. What’s more? The Galaxy Note 10 also comes with super-fast charging. This means that a few minutes of charging will leave you with several hours of battery power. No matter what task you undertake or which business trip you have set out on, trust the Samsung Note 10 to always stick by you. High-end display - You can enjoy the most impressive visual display quality on the Samsung Galaxy Note 10. The model brings to you Infinity Display that makes watching videos a treat. Not only can you multitask while using several applications at a time, but you can also edit different documents and complete important tasks with ease. The Note 10 is designed with a wide 6.3-inch display, which lets you view most things in high quality. If you often like to switch between apps and the innovation of split-screen, then the Galaxy Note 10 will not disappoint. Computing power - The Galaxy Note 10 comes with the Samsung DeX platform that allows you to connect your device with several computing portals. You get to enjoy the best worlds of computing as well as seamless mobile experience. On days you decide to ditch your laptop, the Samsung Galaxy Note 10 will have you covered. Impressive camera quality - Who doesn’t love to flaunt the best in class camera through their phones? The Samsung Galaxy Note 10 features a camera setup that is incredible and delivers the best picture quality. You can capture, edit, and share in an instant. The phone is designed with 3 rear-facing cameras. From depth-sensing to reduced external noise when recording videos, the Galaxy Note 10 allows you to shoot pictures and videos with the best features. Samsung has undoubtedly brought with it an exceptional camera through the Galaxy Note 10. Breeze through tasks with the S Pen - Similar to most Galaxy models, the Galaxy Note 10 includes the S Pen so that your thumbs can take a break. However, it is better refined, so it comes with improved compatibility and several accompanying apps. This makes for better user experience. From a gyroscope to Bluetooth Low Energy connectivity, the S Pen comes with a number of notable features. It makes activities like doodling and jotting down quick notes extremely easy. Moreover, your handwriting can be quickly converted into texts, for the smoothest experience. If you are looking for an upgrade in terms of a larger battery, bigger RAM, better storage, microSD support, and wider display, then the Samsung Galaxy Note 10 Plus is the way to go. The Note 10 Plus, however, is more expensive than the standard Galaxy Note 10.